脓毒血症患者血浆脑尿钠肽水平变化及其与病情严重程度的关系

发布时间：2018-01-18 08:50

本文关键词：脓毒血症患者血浆脑尿钠肽水平变化及其与病情严重程度的关系　出处：《中国老年学杂志》2017年20期 　论文类型：期刊论文

【摘要】：目的探讨脓毒血症患者血浆脑尿钠肽(BNP)水平变化及其与病情严重程度的关系。方法脓毒血症患者60例为研究组,另选取同期健康体检者60例为对照组,入院第1天检测两组血清超敏C反应蛋白(hs-CRP)、降钙素原(PCT),根据28 d内是否死亡将研究组分为死亡组(n=17)和生存组(n=43),入院第1、3天和出重症监护病房(ICU)当天抽取空腹静脉血检测血浆BNP水平,并应用急性生理和慢性健康状况(APACHE)Ⅱ评分评价患者病情,应用Pearson相关分析法分析血浆BNP与APACHE-Ⅱ评分的相关性。结果研究组入院第1天hs-CRP、PCT和BNP水平显著高于对照组(P0.05);死亡组及生存组入院第1天血浆BNP水平和APACHE-Ⅱ评分比较无统计学意义(P0.05),死亡组入院第3天和出ICU当天血浆BNP水平和APACHE-Ⅱ评分均显著高于生存组(P0.05);血浆BNP水平、hs-CRP、PCT与APACHE-Ⅱ评分具有正相关关系(P0.05)。结论脓毒血症患者血浆BNP水平会升高,且与病情严重程度呈正相关,对病情具有一定预测作用。
[Abstract]:Objective to investigate the sepsis patients with plasma brain natriuretic peptide (BNP) level and its relationship with the severity of the disease. Methods 60 cases of sepsis patients as the study group, another 60 cases of healthy people were selected as control group, first days after detection of high sensitivity two groups of serum C reactive protein (hs-CRP), calcitonin the original (PCT), according to whether the death within 28 d were divided into death group (n=17) and survival group (n=43), on the 1,3 day and ICU (ICU) on the day of fasting blood plasma BNP level, and the application of acute physiology and chronic health score (APACHE) the evaluation of patients, analysis of correlation between plasma BNP and APACHE- II scores using Pearson correlation analysis. Results the study group on the first day of hs-CRP, PCT and BNP were significantly higher than those in the control group (P0.05); the death group and survival group on the first day the level of plasma BNP and APACHE- II score comparison Statistical significance (P0.05) and the death group third days after admission and ICU the level of plasma BNP and APACHE- II scores were significantly higher than the survival group (P0.05); the level of plasma BNP, hs-CRP, PCT and APACHE- score had positive correlation (P0.05). Conclusion the level of serum BNP in patients with sepsis will rise, and with serious illness the degree of positive correlation, has certain predictive effect on the disease.

【作者单位】：解放军第一七四医院ICU;安徽医科大学第一附属医院心内科;
【分类号】：R459.7
【正文快照】： 心内科脓毒血症患者超敏C反应蛋白(hs-CRP)、降钙素原(PCT)等炎性指标明显升高,某种程度可评估患者病情程度,但是存在一定争议[1]。脑尿钠肽(BNP)是心脏分泌的利尿肽家族成员之一,能促进排尿和排钠,有效舒张血管,可以对抗肾素-血管紧张素-醛固酮系统,是评价心脏损伤的重要指标

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