组织弥散定量分析技术评估慢性肾脏病肾损害程度的应用价值

发布时间：2018-01-19 21:14

本文关键词： 组织弥散定量分析弹性成像慢性肾脏病　出处：《中国超声医学杂志》2017年04期 　论文类型：期刊论文

【摘要】：目的探讨组织弥散定量分析技术评估慢性肾脏病肾损害程度的临床应用价值。方法选取146例慢性肾脏病(CKD)患者和31例健康体检者,均进行弹性成像组织弥散定量分析检查,所测得的弹性参数进行对比分析,对差异显著的弹性参数与GFR进行相关性分析。结果 (1)%AREA、MEAN、CONT、SD、SKW、COMP弹性参数在CKD3~5期组与对照组组间比较差异均有统计学意义(P0.05)。(2)%AREA、MEAN、CONT、SD、SKW、COMP弹性参数除在CKD1期组与CKD2期组间、CKD4期组与CKD5期组组间比较无统计学意义外(P0.05),其他不同时期CKD组组间比较有统计学意义(P0.05)。(3)%AREA弹性参数与GFR具有较好的相关性,其曲线下面积0.937时,以14.6为临界值,对应的灵敏度及特异度分别89.8%、65.2%。结论组织弥散定量分析技术能够检测并量化CKD患者肾实质弹性,其中弹性参数%AREA对CKD肾损害诊断更具灵敏度,并有望成为检测CKD肾损害程度的敏感指标。
[Abstract]:Objective to evaluate the clinical value of tissue diffusion quantitative analysis in evaluating the degree of renal damage in chronic kidney disease. Methods 146 patients with chronic kidney disease and 31 healthy controls were selected. The elastic parameters were compared and analyzed, and the correlation between the different elastic parameters and GFR was analyzed. There were significant differences in the elastic parameters of SKWCMP between the CKD3~5 group and the control group (P 0.05). The elastic parameters of CKD1 group and CKD2 phase group were divided into two groups. There was no significant difference between CKD4 group and CKD5 group (P0.05). There was a good correlation between the elastic parameters of CKD and GFR, and the area under the curve was 0.937 hours. Taking 14.6 as the critical value, the corresponding sensitivity and specificity were 89.8and 65.20.Conclusion tissue diffusion quantitative analysis can detect and quantify renal parenchyma elasticity in patients with CKD. The elastic parameter area is more sensitive to the diagnosis of renal damage in CKD, and it is expected to be a sensitive index for the detection of renal damage in CKD.
【作者单位】：大连大学附属中山医院超声科;济宁医学院附属第一医院超声科;
【基金】：辽宁省大连市医学卫生科学研究计划项目(No.2014-17)
【分类号】：R445.1;R692
【正文快照】： 作者单位:116000辽宁省大连市,大连大学附属中山医院超声科(胡艳、郭丽苹);济宁医学院附属第一医院超声科(张丽娟)结果(1)%AREA、MEAN、CONT、SD、SKW、COMP弹性参数在CKD3~5期组与对照组组间比较差异均有统计学意义(P0.05)。(2)%AREA、MEAN、CONT、SD、SKW、COMP弹性参数除

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