吸入变应原sIgE在不同气道过敏性疾病儿童中的分布特征

发布时间：2018-01-22 18:31

本文关键词： 变应性鼻炎支气管哮喘吸入变应原特异性IgE 儿童　出处：《中国当代儿科杂志》2017年11期 　论文类型：期刊论文

【摘要】：目的了解不同气道过敏性疾病患儿吸入变应原血清特异性Ig E(slg E)的分布特征。方法应用Uni CAP250变应原定量Ig E检测系统的荧光酶联免疫法,对256例3~14岁气道过敏疾病患儿测定9种常见吸入变应原的血清slg E。256例患儿按临床诊断分为:变应性鼻炎组(简称"鼻炎组",37例)、支气管哮喘组(简称"哮喘组",82例)和变应性鼻炎合并支气管哮喘组(简称"鼻炎并哮喘组",137例)。比较3组患儿9种吸入变应原阳性检出率的分布差异,并比较3组患儿变应原致敏级别和致敏种类数的差异。结果哮喘组、鼻炎组和鼻炎并哮喘组患儿吸入变应原血清s Ig E的阳性检出率分别为57.3%(47/82)、86.5%(32/37)、82.5%(113/137),3组间比较差异有统计学意义(P0.05)。哮喘组、鼻炎组、鼻炎并哮喘组患儿常见变应原均依次为霉菌类(32.9%、54.1%、48.9%)、尘螨类(30.5%、45.9%、46.0%)、花粉类(26.8%、35.1%、32.8%)、宠物类(12.2%、27.0%、18.2%)、蟑螂(9.8%、5.4%、5.8%)。鼻炎组和鼻炎并哮喘组患儿霉菌混合的阳性检出率均高于哮喘组,差异有统计学意义(均P0.0166)。3组患儿9种变应原的致敏级别和致敏种类数比较差异无统计学意义。结论支气管哮喘、变应性鼻炎或二者合并患儿前3位吸入变应原均依次是霉菌类、尘螨类、花粉类;与支气管哮喘相比,霉菌致敏可能与变应性鼻炎关系更密切;这3种常见气道过敏性疾病吸入变应原的致敏分布具有相似性。
[Abstract]:Objective to investigate the specific serum level of inhaled allergens in children with different airway allergies. Methods fluorescence enzyme-linked immunosorbent assay (Elisa) of Uni CAP250 allergen quantitative IgE detection system was used. Serum slg E. 256 cases of patients with airway allergies aged from 3 to 14 years old were divided into allergic rhinitis group (abbreviated as rhinitis group) according to clinical diagnosis of 9 kinds of common inhaled allergen serum slg E.256 cases were divided into two groups: allergic rhinitis group (abbreviated as rhinitis group). There were 37 cases of bronchial asthma, 82 cases of asthma group and 82 cases of allergic rhinitis combined with bronchial asthma group (abbreviated as "rhinitis with asthma group"). 137 cases were compared in the distribution of positive rates of 9 kinds of inhaled allergens in three groups, and the differences of allergen sensitizing grade and number of allergens in 3 groups. Results Asthma group. The positive rate of inhaled allergen serum sIgE in rhinitis group and children with rhinitis and asthma group was 57.3- 47 / 86.5a / 32 / 37, respectively. The difference among the three groups was statistically significant (P 0.05). Asthma group, rhinitis group. The common allergens of children with rhinitis and asthma were 32.9 mildew and 54.1 and 48.9%, and the dust mites 30.5% 45.9% and 46.0% respectively. The amount of the pollen is 35.8%, and the pet type is 12.20.27.0% and 18.2%, and the cockroach 9.8% is 5.4%. The positive rate of mycetes mixed in rhinitis group and rhinitis complicated asthma group was higher than that in asthma group. There was no significant difference in sensitizing grade and number of allergens between the two groups (P 0.0166.3). Conclusion bronchial asthma has no significant difference. The first three inhaled allergens of allergic rhinitis or children with allergic rhinitis or both were mold, dust mite and pollen. Compared with bronchial asthma, fungal sensitization may be more closely related to allergic rhinitis. The sensitizing distribution of inhaled allergens in these three common airway allergies is similar.
【作者单位】：首都医科大学附属北京儿童医院/国家儿童医学中心过敏反应科;
【基金】：北京市科技专项(Z131100006813044)
【分类号】：R446.6;R725.6
【正文快照】： 变应性鼻炎和支气管哮喘是儿童时期最常见的呼吸道变态反应性疾病。虽然两者的病变部位有所不同,但上下气道变应性炎症的一致性已达成共识[1],约有30%的变应性鼻炎患儿合并哮喘,30%~70%的哮喘患儿伴有变应性鼻炎[2-4]。吸入性变应原是变应性鼻炎和哮喘的首要变应原,明确不同气

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