衰减全反射傅里叶变换红外光谱技术的临床应用研究进展

发布时间：2018-01-25 03:09

本文关键词： 衰减全反射傅里叶变换红外光谱血清恶性肿瘤　出处：《光谱学与光谱分析》2017年02期 　论文类型：期刊论文

【摘要】：系统回顾了衰减全反射傅里叶变换红外光谱(attenuated total reflection Fourier transform infrared,ATR-FTIR)技术在临床医学领域中的应用研究进展。ATR-FTIR光谱技术具有实时、简单、无创扫描生物组织样品的优势,通过结合多模式识别统计学方法并对照临床及病理学诊断结果,可对生物组织样本进行判别分析。目前,对甲状腺、乳腺,以及肺组织等新鲜离体组织的光谱学检测中,ATR-FTIR技术可达到较高的判别敏感性、准确性与特异性;尤其在对甲状腺和乳腺疾病患者的前哨淋巴结活检的研究中,应用ATR-FTIR技术,可对良、恶性组织进行敏感性、准确性与特异性均较高的鉴别研究,对辅助临床诊断具有潜在的重要价值。此外,利用ATR-FTIR光谱技术对生物体液进行光谱分析并进一步诊断疾病的研究也在逐步开展。由于血清中所含成分的改变对于提示疾病状况具有重要价值,因而血清ATR-FTIR光谱学诊断方法成为研究热点,已有应用ATR-FTIR技术对脑胶质细胞瘤、心肌梗死、肾衰、阿尔茨海默病、卵巢癌与子宫内膜癌等多种疾病进行分析的研究报道。目前已可通过ATR-FTIR技术对卵巢癌进行疾病分期的判别诊断,该技术有望成为卵巢癌筛查的重要方法。由于血清ATR-FTIR光谱学技术具有检测快速、判别准确、性价比高等优势,有望成为今后生物医学发展的重要方向之一。
[Abstract]:The attenuated total reflection Fourier transform infrared (FTIR) spectra are systematically reviewed. Attenuated total reflection Fourier transform infrared. Advances in the Application of ATR-FTIR in Clinical Medicine. ATR-FTIR spectroscopy has the advantages of real-time, simple and non-invasive scanning of biological tissue samples. By combining the statistical method of multi-pattern recognition and comparing the clinical and pathological diagnosis results, we can make discriminant analysis on the samples of biological tissue. At present, the thyroid gland and mammary gland can be analyzed. In addition, ATR-FTIR can achieve high sensitivity, accuracy and specificity in the spectral detection of fresh isolated tissues such as lung tissue. Especially in the study of sentinel lymph node biopsy in patients with thyroid and breast diseases, ATR-FTIR technique can be used to identify benign and malignant tissues with high sensitivity, accuracy and specificity. It has potential important value for auxiliary clinical diagnosis. The study of spectrum analysis of biological body fluid and further diagnosis of diseases by ATR-FTIR spectroscopy is also being carried out step by step. Because of the changes of the components in the serum, it is of great value to indicate the status of the disease. Therefore, serum ATR-FTIR spectroscopy diagnosis method has become a hot research, ATR-FTIR technology has been used in the treatment of brain glioma, myocardial infarction, renal failure, Alzheimer's disease. Studies on ovarian cancer and endometrial carcinoma are reported. At present, ATR-FTIR can be used to diagnose the stage of ovarian cancer. This technique is expected to become an important method for ovarian cancer screening. Due to the rapid detection of serum ATR-FTIR spectroscopy, accurate discrimination, high performance-to-price ratio and other advantages. It is expected to be one of the important directions of biomedical development in the future.
【作者单位】：北京大学第三医院麻醉科;中日友好医院乳甲外科;杭州师范大学;北京大学化学与分子工程学院;北京大学第三医院普通外科;
【基金】：国家自然科学基金面上项目(81371205)资助
【分类号】：R446;O657.33
【正文快照】： 1.北京大学第三医院麻醉科,北京1001912.中日友好医院乳甲外科,北京1000293.杭州师范大学,浙江杭州3111214.北京大学化学与分子工程学院,北京1008715.北京大学第三医院普通外科,北京100191引言衰减全反射傅里叶变换红外光谱(attenuated total reflec-tion Fourier transform i

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