自身免疫性脑炎临床表现与MRI特征分析

发布时间：2018-01-27 04:27

本文关键词： 自身免疫性脑炎临床表现 MRI　出处：《中国神经精神疾病杂志》2017年06期 　论文类型：期刊论文

【摘要】：目的对自身免疫性脑炎的临床症状与MRI特征进行分析,提高临床医师对自身免疫性脑炎的临床特征及MRI表现的认识。方法纳入自身免疫性脑炎33例,收集一般临床资料,采用MRI观察颅内病变情况,分析其主要症状及影像学特征。结果本组自身免疫性脑炎的主要症状为精神行为异常27例(81.8%),癫痫发作26例(78.8%),18例(54.5%),发热11例(33.3%),中枢性低通气9例(27.3%)等,其中不自主运动和发热发生率LE组较NMDA组低。MRI阳性者10例,脑实质受累8例,脑膜受累3例,脑实质依次累及枕叶、双侧海马、额叶、顶叶、颞叶及丘脑、小脑等部位。结论精神行为异常及癫痫发作为自身免疫性脑炎最常见的两个症状,MRI可发现边缘系统异常信号,其中FLAIR序列最为敏感。
[Abstract]:Objective to analyze the clinical symptoms and MRI features of autoimmune encephalitis and to improve the clinical features and MRI manifestations of autoimmune encephalitis. Methods 33 cases of autoimmune encephalitis were included. General clinical data were collected and intracranial lesions were observed by MRI. Results the main symptoms of autoimmune encephalitis were mental and behavioral abnormality in 27 cases and epileptic seizure in 26 cases (78.8%). There were 18 cases with 54.5D, 11 cases with fever, 33.3 cases with fever, 9 cases with central hypopnea and 27.3 cases with central hypopnea. The incidence of involuntary movement and fever in le group was lower than that in NMDA group (10 cases), cerebral parenchyma involvement (8 cases) and meningeal involvement (3 cases). The cerebral parenchyma involved occipital lobe, bilateral hippocampus, frontal lobe and parietal lobe in turn. Conclusion abnormal mental behavior and seizure are the two most common symptoms of autoimmune encephalitis. FLAIR sequence is the most sensitive.
【作者单位】：重庆医科大学附属第一医院神经内科;重庆医科大学附属第一医院放射科;
【分类号】：R445.2;R742.9
【正文快照】： 近年来,随着越来越多的抗细胞表面抗原抗体被认识及抗体检测技术的不断发展,越来越多的自身免疫性脑炎(autoimmune encephalitis,AE)被诊断,其中最常见的为抗NMDA受体脑炎。其诊断主要依靠临床表现、头颅MRI及血清和(或)脑脊液的相关抗体。现将我院近3年经抗体诊断的AE患者的

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