淮安市儿童急性呼吸道感染病原学分析

发布时间：2018-01-28 01:22

本文关键词： 儿童急性呼吸道感染病原体间接免疫荧光法　出处：《中国现代医学杂志》2017年23期 　论文类型：期刊论文

【摘要】：目的探讨急性呼吸道感染(ARI)患儿呼吸道病原体的感染情况及季节流行特点,为临床实施行之有效地预防和诊治提供依据。方法应用间接免疫荧光法(IFA)检测该院2015年1月-2015年12月3 461例0~12岁ARI患儿血清中呼吸道合胞病毒(RSV)、腺病毒(ADV)、甲型流感病毒(Flu A)、乙型流感病毒(Flu B)、副流感病毒(PIV)、肺炎支原体(MP)、肺炎衣原体(CP)、嗜肺军团菌(LP)Ig M抗体。结果 3 461份血清中呼吸道感染病原体Ig M抗体阳性检出率为69.17%,最常检测到的病原体是Flu B(51.11%)、Flu A(36.38%)、MP(25.14%)和RSV(9.04%)。Flu A、Flu B和MP感染无明显季节性,检出率整年均较高;RSV呈现流行高峰在冬、春季;ADV和CP为春、夏季多发;PIV和LP发病率终年较低。随年龄增长RSV发病率下降,而其他病原体则相反。病原体混合感染检出1 627例,占47.01%;混合感染最常见病原体为Flu A+Flu B和Flu A+Flu B+MP。结论淮安地区2015年8种呼吸道病原体阳性率达69.17%,以Flu B检出率最高;呼吸道病原体感染的流行季节各有不同;伴随年龄的增长RSV阳性率降低,而其他病原体阳性率则逐步增长;以Flu A和Flu B的混合感染为最多见;早期检测呼吸道病原体,将有助于儿科医生诊治和控制呼吸道感染。
[Abstract]:Objective to investigate the infectious status and seasonal epidemic characteristics of respiratory pathogens in children with acute respiratory infection (ARI). Methods indirect immunofluorescence method was used to provide evidence for effective prevention, diagnosis and treatment. Serum respiratory syncytial virus (RSV) was detected in 461 children aged from 0 to 12 years old with ARI from January 2015 to December 3rd 2015. Adenovirus (ADV), influenza A virus (flu au), influenza B virus (Flu), parainfluenza virus (PIVV), Mycoplasma pneumoniae (MPP), Chlamydia pneumoniae (CPP). Results the positive rate of IgG antibody against respiratory tract infection in 3 461 sera was 69.17%. The most commonly detected pathogens were Flu Bm51.11 / Flu au 36.38 and RSV(9.04%).Flu A. The infection rate of Flu B and MP was high all year round. The peak of RSV was in winter and spring. ADV and CP were mostly in spring and summer. The incidence of PIV and LP was lower all year round. The incidence of RSV decreased with age, but the other pathogens were opposite. 1627 cases (47.01%) of mixed infection were detected. The most common pathogens of mixed infection were Flu A Flu B and Flu A Flu B MP.Conclusion in 2015, the positive rate of 8 kinds of respiratory pathogens in Huaian area was 69.17%. The detection rate of Flu B was the highest. The epidemic season of respiratory tract pathogen infection is different; With the increase of age, the positive rate of RSV decreased, while the positive rate of other pathogens increased gradually. The mixed infection of Flu A and Flu B was the most common. Early detection of respiratory pathogens will help pediatricians to treat and control respiratory infections.
【作者单位】：南京医科大学附属淮安第一医院检验科;
【分类号】：R446.6;R725.6
【正文快照】： 急性呼吸道感染(acute respiratory infection,ARI)是儿科常见的感染性疾病,在发展中国家更是对儿童健康主要的、严重的威胁。病毒、非典型性病原体是引发ARI的多见病因[1-3]。本研究检测2015年淮安地区本院儿科门诊和住院3 461例ARI儿童血清8种呼吸道病原体免疫球蛋白M(immun

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