~1H-MRS分析对侵袭性垂体腺瘤的诊断价值

发布时间：2018-02-17 04:14

本文关键词： 垂体腺瘤磁共振波谱成像胆碱肌酸 N-乙酰天门冬氨酸　出处：《放射学实践》2017年04期 　论文类型：期刊论文

【摘要】：目的:探讨~1H-磁共振波谱成像(~1H-MRS)对侵袭性垂体腺瘤的诊断价值。方法:对56例经病理证实的垂体腺瘤患者的~1H-MRS数据进行回顾性分析,其中侵袭性36例、非侵袭性20例。测量和计算两组患者病变区的胆碱(Cho)/肌酸(Cr)、N-乙酰天门冬氨酸(NAA)/Cr、肌醇(MI)/Cr、乳酸脂质(LL)/Cr及Cho/NAA的值,并进行统计学分析。结果:Cho/Cr、LL/Cr、MI/Cr、NAA/Cr及Cho/NAA的值在侵袭性组中分别为3.913±2.091、2.435±1.645、1.466±1.319、1.169±0.781及3.865±1.890,在非侵袭性组中分别为1.796±0.612、3.552±2.716、1.340±1.010、1.069±0.774和1.799±0.581,两组间仅Cho/NAA和Cho/Cr的差异有统计学意义(P0.05)。受试者工作特征(ROC)曲线分析显示,当Cho/NAA值大于2.045时,诊断侵袭性垂体腺瘤的敏感度为89.9%,特异度为80.0%,符合率为88.5%;当Cho/Cr值大于1.900时,诊断侵袭性垂体腺瘤的敏感度为86.1%,特异度为65.0%,符合率为83.6%。结论:~1H-MRS对侵袭性垂体腺瘤的诊断具有一定参考价值。
[Abstract]:Objective: to evaluate the diagnostic value of 1H-MRS in invasive pituitary adenomas. Methods: retrospective analysis was performed in 56 cases of pituitary adenomas confirmed by pathology, including 36 cases of invasive pituitary adenomas. Twenty cases of noninvasive. The values of choline chorion / creatine (Cr) -acetyl aspartic acid (NAA / Cr), inositol (Mi / Cr), lactate lipids (LLX / Cr) and Cho/NAA were measured and calculated in the two groups. Results the values of NAA / Cr and Cho/NAA in the invasive group were 3.913 卤2.091 卤2.435 卤1.6451.466 卤1.3191.169 卤0.781 and 3.865 卤1.890, respectively, and 1.796 卤0.6123.552 卤2.716 卤1.340 卤1.0101.069 卤0.774 and 1.799 卤0.581in the non-invasive group, respectively. The difference between the two groups was significant (P 0.05). When the Cho/NAA value was greater than 2.045, the sensitivity, specificity and coincidence rate of diagnosis of invasive pituitary adenomas were 89.9, 80.0and 88.5respectively, and when the Cho/Cr value was greater than 1.900, the sensitivity and specificity were 80.0 and 87.5, respectively. The sensitivity, specificity and coincidence rate of diagnosis of invasive pituitary adenomas were 86.1 and 65.0 respectively.
【作者单位】：第三军医大学新桥医院放射科;
【基金】：国家自然科学基金(81501521)
【分类号】：R445.2;R736.4

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