基于化学发光法建立深圳地区健康儿童性激素的参考区间

发布时间：2018-02-20 19:21

本文关键词： 性激素化学发光法参考区间儿童　出处：《中国当代儿科杂志》2017年12期 　论文类型：期刊论文

【摘要】：目的建立深圳地区0~18岁健康儿童性激素6项,即黄体生成素、促卵泡生成素、孕酮、泌乳素、雌二醇、睾酮化学发光法的参考区间值。方法采用分层整群抽样的方法于2015年9月至2016年9月在深圳市福田、罗湖、南山、宝安、龙岗5个区随机抽取0~18岁健康儿童2?178例(男童1?219例,女童959例),包括新生儿81例,婴儿335例,幼儿346例,学龄前儿童469例,学龄期儿童419例,青春期儿童528例。利用美国贝克曼DXI800化学发光仪测定黄体生成素、促卵泡生成素、孕酮、泌乳素、雌二醇、睾酮6项性激素水平。结果黄体生成素、促卵泡生成素、孕酮、泌乳素、雌二醇和睾酮在不同年龄组间水平不同,差异有统计学意义(P0.05)。同年龄组不同性别间的性激素水平的比较差异也有统计学意义(P0.05)。基于各年龄组不同性别儿童的6项激素检测水平,建立了深圳地区0~18岁健康儿童性激素6项的参考区间。结论深圳地区0~18岁健康儿童不同年龄组和不同性别组的性激素水平存在差异。该研究建立的不同性别的各年龄组的性激素6项的参考区间对儿童内分泌相关疾病的诊断与治疗有重要意义。
[Abstract]:Objective to establish six sex hormones, namely luteinizing hormone, follicle stimulating hormone, progesterone, prolactin, estradiol, in 18 year old healthy children in Shenzhen area. The reference interval value of testosterone chemiluminescence method. Methods A stratified cluster sampling method was used from September 2015 to September 2016 in 5 districts of Shenzhen City, Futian, Luohu, Nanshan, Baoan and Longgang to randomly select 2? 178 cases (male 1? There were 219 cases of girls, including 81 newborns, 335 infants, 346 young children, 469 preschool children, 419 school-age children and 528 adolescent children. Luteinizing hormone was determined by Beckman DXI800 chemiluminescence instrument. Results the levels of luteinizing hormone, follicle stimulating hormone, progesterone, prolactin, estradiol and testosterone were different in different age groups. The difference was statistically significant (P 0.05). There were also significant differences in sex hormone levels among different genders of the same age group. A reference interval of 6 items of sex hormones for healthy children aged 0 to 18 years in Shenzhen area was established. Conclusion there are differences in sex hormone levels among different age groups and different sex groups of healthy children aged 0 to 18 years old in Shenzhen area. The reference interval of 6 items of sex hormone in age group is of great significance for the diagnosis and treatment of endocrine related diseases in children.
【作者单位】：深圳市儿童医院检验科;中山大学公共卫生学院;
【基金】：深圳市2015年基础研究知识创新计划项目(JCYJ20150403100317063)
【分类号】：R446.1

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