Sysmex XN-3000全自动血细胞分析流水线血小板聚集报警信息的可信性分析

发布时间：2018-02-21 19:00

本文关键词： 全自动血细胞分析仪血小板聚焦警示信息　出处：《山东医药》2017年08期 　论文类型：期刊论文

【摘要】：目的分析Sysmex XN-3000全自动血细胞分析流水线(以下简称XN-3000)血小板聚集报警信息的可信性,并探讨其对血小板聚集的最佳诊断阈值。方法选取血液标本503例份,分别采用XN-3000和人工镜检判断血小板聚集情况。以人工镜检结果为金标准,分析XN-3000警示值对血小板聚集的判断价值,并分析两种方法检测结果的关系。绘制受试者工作特征(ROC)曲线,分析XN-3000对血小板聚集的最佳诊断阈值。结果 XN-3000检测血小板聚集阳性158例份、阴性345例份,人工镜检血小板聚集阳性181例份、阴性322例份。XN-3000警示值判断血小板聚集的敏感性为76.2%,特异性为93.8%,阳性预测值为87.3%,阴性预测值为87.5%,准确性为87.5%。Pearson相关分析显示,XN-3000警示值与人工镜检血小板聚集阳性率呈正相关(r=0.987,P0.01)。ROC曲线分析显示,XN-3000警示值判断血小板聚集的最佳临界值为80,此时敏感性为87.8%、特异性为91.6%、AUC为0.92。结论 XN-3000警示值判断血小板聚集的可信性较高,其最佳诊断阈值为80。
[Abstract]:Objective to analyze the credibility of Sysmex XN-3000 automatic blood cell analysis on the alarm information of platelet aggregation of pipeline (XN-3000) and to explore the optimal diagnostic threshold for platelet aggregation. The platelet aggregation was judged by XN-3000 and artificial microscope, and the value of XN-3000 warning value in judging platelet aggregation was analyzed with the results of artificial microscope as gold standard. The relationship between the results of the two methods was analyzed. The operating characteristics of the subjects were drawn and the optimal diagnostic threshold of platelet aggregation by XN-3000 was analyzed. Results XN-3000 was positive in 158 cases and negative in 345 cases. 181 cases of platelet aggregation were examined by artificial microscope. The sensitivity, specificity, positive predictive value, negative predictive value, accuracy and accuracy of XN-3000 warning value for platelet aggregation in 322 negative cases were 76.2, 93.8, 87.3, 87.5, 87.5, 87.5, 87.5, 87.5, 87.5, 87.5, 87.5, 87.5, 87.5, 87.5, 87.5, 87.5, 87.5, 87.5, 87.5, 87.5, 87.5, 87.5, 87.5, 87.5, 87.5, and 87.5, respectively, respectively. The positive correlation curve analysis showed that the best critical value for judging platelet aggregation was 80, the sensitivity was 87.8, and the specificity was 91.6AUC was 0.92.Conclusion the XN-3000 warning value is reliable in judging platelet aggregation. The optimal diagnostic threshold is 80. 0%.
【作者单位】：深圳市儿童医院;
【基金】：深圳病原体高通量基因测序技术工程实验室项目(深发改委[2014]1712号) 深圳市科技计划项目(JCYJ20140416141331504)
【分类号】：R446.11

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