动脉自旋标记技术对脑胶质瘤术前分级准确性的Meta分析

发布时间：2018-02-23 23:21

本文关键词： 脑肿瘤神经胶质瘤磁共振成像磁共振血管造影术 Meta分析　出处：《中国医学影像学杂志》2017年09期 　论文类型：期刊论文

【摘要】：目的对用动脉自旋标记(ASL)技术在术前进行脑胶质瘤高低分级的文献进行Meta分析,评估ASL技术在术前预测脑胶质瘤级别的价值。资料与方法检索Pub Med、Cochrane Library、Web of Science、中国生物医学文献数据库(CBM)、中国知网(CNKI)和万方数据库中1992年1月—2016年10月发表的相关中、英文文献,纳入符合要求的文献,提取相关资料和参数,运用Rev Man 5.3、Meta-Disc 1.4及Stata 12软件进行Meta分析。结果符合纳入标准的文献共11篇,诊断数据为3组标准化灌注参数:肿瘤最大血流量/对侧正常白质血流量、肿瘤最大血流量/对侧正常灰质血流量、肿瘤最大血流量/对侧大脑半球血流量,各组诊断参数均不存在异质性。汇总诊断敏感度分别为0.87(95%CI 0.82~0.92)、0.88(95%CI 0.79~0.94)、0.95(95%CI 0.89~0.98),汇总特异度分别为0.89(95%CI 0.83~0.94)、0.90(95%CI 0.79~0.96)、0.92(95%CI 0.81~0.97),各组相对应的综合受试者工作特性曲线下面积分别为0.9418、0.9443、0.9468。结论 ASL技术的标准化参数肿瘤最大血流量/对侧正常白质血流量、肿瘤最大血流量/对侧正常灰质血流量术前预测脑胶质瘤分级准确性较好。肿瘤最大血流量/对侧大脑半球血流量组文献存在发表偏倚,需今后进一步验证其诊断价值。
[Abstract]:Objective to study the Meta analysis of the high and low grade of brain glioma by arterial spin labeling (ASL) technique before operation. To evaluate the value of ASL technique in predicting the grade of brain glioma before operation. Data and methods the relevant Chinese and English literatures published in Pub Med#en1# Cochrane Library Web of Science, China Biomedical Literature Database and Wanfang Database from January 1992 to October 2016 were searched. The relevant data and parameters were extracted, and Meta analysis was carried out with Rev Man 5.3 Meta-Disc 1.4 and Stata 12 software. The diagnostic data were as follows: tumor maximum blood flow / contralateral normal white matter flow, tumor maximum blood flow / contralateral normal gray matter blood flow, tumor maximum blood flow / contralateral cerebral hemispheric blood flow. There was no heterogeneity in the diagnostic parameters in each group. The diagnostic sensitivity of each group was 0.8795 CI 0.820.882.95 CI 0.790.790.95 and CI 0.890.890.98, and the sum specificity was 0.8995CI 0.830.940.9095CI 0.790.96CI 0.790.96CI. the area under the comprehensive operating characteristic curve of each group was 0.94180.4430.9468.Conclusion the area under the working characteristic curve of each group is 0.94180.4430.9468. Standard parameters of tumor maximum blood flow / contralateral normal white matter blood flow, The accuracy of preoperative prediction of glioma grade by tumor maximum blood flow / contralateral normal gray matter blood flow was good, and the publication bias existed in the tumor maximum blood flow / contralateral cerebral hemispheric blood flow group, which needed to be further verified in the future.
【作者单位】：石河子大学医学院第一附属医院CT/MR室;
【分类号】：R445.2;R739.41

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