钆对比剂安全性评价

发布时间：2018-02-24 11:13

本文关键词： 钆对比剂特征急性不良反应迟发性不良反应　出处：《中国医学计算机成像杂志》2017年05期 　论文类型：期刊论文

【摘要】：钆对比剂是含有顺磁性金属离子Gd~(3+)的螯合物,能够通过增强T1加权像上的信号强度,提高病灶与正常组织的对比度及显示病灶的血流动力学特征,对磁共振成像技术的革新和发展有很大的帮助,近年来使用率呈逐年增加的趋势。自1987年首个钆对比剂被FDA批准上市,目前共9种钆对比剂投入临床使用,不同种类的钆对比剂的稳定性主要取决于各种类型分子结构的热力学常数、动力学稳定常数和条件稳定常数,动物实验及临床研究均证实了使用钆对比剂后钆在体内各组织器官的沉积。尽管目前临床普遍认为钆对比剂是安全的,但仍有部分患者发生不良反应,头痛、恶心、味觉改变和荨麻疹是最常见的不良反应,极少数患者可能发生过敏性休克或远期发生肾源性系统性纤维化。本文旨在通过对大量文献进行回顾分析及本院数据总结,对钆对比剂的主要特征和不良反应进行了详细的介绍,以利于将钆对比剂更安全地应用于临床。
[Abstract]:Gadolinium contrast agent is a chelate containing paramagnetic metal ion Gd~(3, which can enhance the contrast between the lesion and the normal tissue and display the hemodynamic characteristics of the lesion by enhancing the signal intensity on the T1 weighted image. It is of great help to the innovation and development of magnetic resonance imaging technology, and the utilization rate is increasing year by year in recent years. Since 1987, when the first gadolinium contrast agent was approved by FDA, nine kinds of gadolinium contrast agents have been put into clinical use. The stability of different gadolinium contrast agents mainly depends on the thermodynamic constants, kinetic stability constants and conditional stability constants of various molecular structures. Animal experiments and clinical studies have confirmed the deposition of gadolinium in various tissues and organs after the use of gadolinium contrast agent. Although it is generally accepted that gadolinium contrast agent is safe in clinical practice, some patients still have adverse reactions, headache, nausea, Taste changes and urticaria are the most common adverse reactions, and very few patients may develop anaphylactic shock or long-term renal systemic fibrosis. The main characteristics and adverse reactions of gadolinium contrast agent were introduced in detail to facilitate the safe application of gadolinium contrast agent in clinical practice.
【作者单位】：四川大学华西医院放射科;
【分类号】：R445.2

【相似文献】