2型糖尿病患者血清正五聚蛋白3与代谢指标相关性的分析

发布时间：2018-03-03 14:19

本文选题：正五聚蛋白　切入点：型糖尿病　出处：《重庆医学》2017年16期 　论文类型：期刊论文

【摘要】：目的探讨血清正五聚蛋白(PTX)3水平在2型糖尿病(T2DM)患者不同体质量指数(BMI)组中的变化及与代谢指标的相关性。方法 164例T2DM患者根据BMI分为体质量正常组(A组)53例、超重组(B组)56例及肥胖组(C组)55例,采用酶联免疫法测定各组血清PTX3水平,分析血清PTX3水平与BMI、血糖、血脂、胰岛素抵抗指数(HOMA-IR)等的关系。结果血清PTX3水平在A、B、C组分别为(3.46±0.19)、(2.47±0.21)、(1.44±0.18)ng/mL,组间两两比较,差异有统计学意义(P0.05)。PTX3水平与BMI、TG、LDL-C、空腹胰岛素(Fins)、HOMA-IR负相关(r分别为-0.897、-0.621、-0.232、-0.593、-0.487,P0.01或P0.05),多元逐步回归分析显示,BMI、HOMA-IR与PTX 3水平独立相关。结论 T2DM患者中,BMI、HOMA-IR是影响血清PTX 3水平降低的独立危险因素。
[Abstract]:Objective to investigate the changes of serum PTX3 levels in patients with type 2 diabetes mellitus (T2DM) with different body mass index (BMI) and their correlation with metabolic indexes. Methods according to BMI, 164 patients with T2DM were divided into normal body weight group (n = 53) and normal body weight group (n = 53). Serum PTX3 levels were measured by enzyme-linked immunosorbent assay (Elisa) in 56 cases of hyperrecombination group B and 55 cases of obese group C. The levels of serum PTX3, BMI, blood glucose, blood lipids were analyzed by enzyme-linked immunosorbent assay (Elisa). Results the serum PTX3 levels were 3.46 卤0.19 in group A and 2.47 卤0.21 in group A (1.44 卤0.18 ng / mL). There was significant difference between the levels of BMIHOMA-IR and LDL-C of BMI-TGG, the negative correlation r of fasting insulin with HOMA-IR was -0.897h-0.621- 0.232mg-0.593n- 0.487U P0.01 or P0.05. multiple stepwise regression analysis showed that BMIHOMA-IR was independently correlated with the level of PTX3 in T2DM patients. Conclusion BMIHOMA-IR is an independent risk factor for the decrease of serum PTX3 level in patients with T2DM.
【作者单位】：三峡大学仁和医院检验科;
【分类号】：R446.1;R587.1

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