老年急性心肌梗死患者甲状腺激素与高敏C反应蛋白检测的临床意义

发布时间：2018-03-21 02:47

本文选题：急性心肌梗死　切入点：甲状腺激素　出处：《中国老年学杂志》2017年22期 　论文类型：期刊论文

【摘要】：目的探讨老年急性心肌梗死(AMI)患者甲状腺激素及高敏C反应蛋白(hs-CRP)水平变化及其检测的临床意义。方法 89例AMI患者作为AMI组,另选取健康体检者80例作为对照组,比较两组甲状腺激素及hs-CRP水平;依据游离三碘甲状腺原氨酸(FT3)三分位分为3组,比较3组性别、年龄、血糖、血脂、hs-CRP、心肌损伤标志物、游离甲状腺素(FT4)及促甲状腺素(TSH)水平,并分析FT3、FT4、TSH及hs-CRP与其余指标的相关性。结果 AMI组FT3水平显著低于对照组,hs-CRP水平显著高于对照组(P0.05);与高值组相比,中值组和低值组hs-CRP、肌酸激酶同工酶(CK-MB)和心肌肌钙蛋白(c Tn)I水平均显著降低,且低值组显著低于中值组(P0.05);中值组和低值组TSH水平显著高于高值组,且低值组显著高于中值组(P0.05);FT3水平与hs-CRP、CK-MB、c Tn I水平呈显著负相关(P0.05),FT4水平与c Tn I呈显著负相关(P0.05),hs-CRP水平与总胆固醇(TC)、CK-MB、c Tn I水平呈显著正相关(P0.05),TSH水平与上述指标无相关性。结论老年AMI患者存在甲状腺激素水平异常,且伴有hs-CRP水平升高,AMI患者FT3及hs-CRP可作为评估患者心肌损伤程度及预后的重要检测指标。
[Abstract]:Objective to investigate the changes of thyroid hormone and Gao Min C-reactive protein hs-CRP in elderly patients with acute myocardial infarction (AMI) and their clinical significance. Methods 89 patients with AMI as AMI group and 80 healthy persons as control group. The thyroid hormones and hs-CRP levels were compared between the two groups, and were divided into 3 groups according to free triiodothyronine FT3. The sex, age, blood glucose, blood lipid levels of hs-CRP, myocardial injury markers, free thyroxine FT4) and thyrotropin TSH were compared among the three groups. Results the level of FT3 in AMI group was significantly lower than that in control group (P 0.05), and was significantly higher than that in control group (P 0.05). The levels of hs-CRP, creatine kinase isoenzyme (CK-MBB) and cardiac troponin C Tn)I in the median group and the low value group were significantly lower than those in the median group and the low value group, and the levels of TSH in the median group and the low value group were significantly higher than those in the high value group. The low value group was significantly higher than the median group, the level of FT3 was significantly higher than that of the median group. There was a significant negative correlation between the level of hs-CRP, CK-MBN, c TnI, and the level of P0.05, FT4, and the level of c TnI. There was no significant positive correlation between the level of CRP and the level of total cholesterol, CK-MBc, TnI, and the level of TSH, which was not correlated with the above indexes. Conclusion there is abnormal thyroid hormone level in elderly patients with AMI. FT3 and hs-CRP can be used as an important index to evaluate the degree and prognosis of myocardial injury in patients with hs-CRP.
【作者单位】：武汉市第三医院光谷院区检验科;湖北省肿瘤医院核医学科;
【分类号】：R446.1;R542.22

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