血浆Presepsin水平在脓毒症早期诊断中的价值研究

发布时间：2018-03-21 20:27

  本文选题：可溶性白细胞分化抗原亚型　切入点：降钙素原　出处：《中华医院感染学杂志》2017年21期 　论文类型：期刊论文

【摘要】：目的探讨血浆可溶性白细胞分化抗原14亚型(Presepsin)水平对脓毒症早期诊断和病情评估的临床价值。方法采用前瞻性研究方法选取2016年9月-12月医院重症监护病房(ICU)住院治疗的80例危重病患者,依据脓毒症诊断标准分为脓毒症组40例、脓毒症休克组40例,选择同期20例健康体检者为对照组,入院时检测所有研究对象血浆Presepsin、降钙素原(PCT)、超敏C-反应蛋白(hs-CRP)水平,并进行急性生理学与慢性健康状况评分系统Ⅱ(APACHEⅡ)评分和序贯性器官功能衰竭(SOFA)评分,采用Pearson或Spearman相关分析法分析Presepsin与PCT、APACHEⅡ评分、SOFA评分的相关性;采用受试者工作特征曲线(ROC)评估Presepsin、PCT、hs-CRP对脓毒症的诊断价值。结果脓毒症休克组血浆Presepsin、PCT及hs-CRP水平均明显高于脓毒症组和健康对照组(P0.01);脓毒症休克组APACHEⅡ评分和SOFA评分高于脓毒症组(P0.01);Pearson相关分析结果显示,Presepsin与PCT呈显著正相关(r=0.517,P0.01);Spearman相关分析结果显示,Presepsin与APACHEⅡ评分、SOFA评分呈显著正相关(r=0.554,r=0.605,P0.01);ROC曲线分析显示:Presepsin、PCT、hs-CRP诊断脓毒症时的ROC曲线下面积(AUC)分别为(0.917,P0.001;0.691,P0.001;0.625,P0.05)。结论血浆Presepsin水平可作为脓毒症患者早期诊断及评估病情严重程度和预后的有效指标。
[Abstract]:Objective to investigate the clinical value of plasma soluble leukocyte differentiation antigen 14 subtype Presepsin in the early diagnosis and evaluation of sepsis. Methods A prospective study was conducted to select ICU in hospital intensive care unit from September to December 2016. 80 critically ill patients treated in hospital, According to the diagnostic criteria of sepsis, the patients were divided into sepsis group (n = 40), septic shock group (n = 40) and control group (n = 20). The plasma levels of Presepsinin, procalcitonin (PCT), hypersensitive C-reactive protein (hs-CRP) were measured on admission. The acute physiology and chronic health status scoring system 鈪，

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