肠易激综合征患者静息态脑功能磁共振成像研究

发布时间：2018-03-21 22:32

本文选题：肠易激综合征　切入点：静息态功能磁共振成像　出处：《浙江大学》2017年硕士论文　论文类型：学位论文

【摘要】：目的:通过分析肠易激综合征患者静息态fMRI神经影像学特征,探讨IBS患者可能的中枢发病机制。方法:纳入符合2006年罗马III标准的腹泻型肠易激综合征(IBS-D)患者30例以及在性别、年龄、利手、受教育程度与患者相匹配的非IBS健康志愿者30例。所有受试者给予Siemens 3T超导磁共振静息态成像,解剖图像用三维快速扰相梯度翻转恢复(3D-FSPGR)序列采集,fMRI扫描序列采用T2-平面回波成像一梯度回波(EPI-GRE)序列。扫描完成后运用"DPARSF"软件对数据进行预处理,功能连接的种子区选择丘脑,以"REST"软件中两独立样本t检验进行分析,采用局部一致性(ReHo)、低频涨落振幅(ALFF)、功能连接(FC)作为评价指标,比较IBS组和健康对照组之间静息态下ALFF、ReHo、FC的差异并进行相关性分析。结果:(1)ReHo值比较:与健康对照组相比,IBS患者ReHo降低的区域包括双侧前扣带回、两侧额叶、左侧岛叶;增高的区域包括右额眶回、两侧颞叶、两侧枕叶及两侧小脑后叶(两独立样本t检验,P0.001,校正后)。(2)ALFF值比较:与健康对照组相比,IBS组静息状态表现出ALFF增强的脑区包括双侧丘脑、右侧海马、左侧海马旁回、双侧顶下回、右侧小脑前叶、小脑蚓部、双侧枕下回、左枕中回;ALFF值减弱的脑区有双侧额叶、左前扣带回、右侧岛叶(两独立样本t检验,P0.001,校正后)。(3)丘脑的功能连接比较:与健康对照组相比,IBS组后扣带回及两侧丘脑前核群连接增强,左楔叶连接减弱(两独立样本t检验,P0.01,校正后)。结论:静息状态下,IBS患者存在大脑疼痛处理相关脑区功能异常以及大脑网络功能失调,这可能涉及IBS中枢发病机制,值得深入研究。
[Abstract]:Objective: to study the neuroimaging characteristics of resting fMRI in patients with irritable bowel syndrome (IBS) and to explore the possible central pathogenesis of IBS. Age, handy, and educated non IBS healthy volunteers. All subjects were given Siemens 3T superconducting magnetic resonance resting imaging. The scanning sequence of fMRI was collected by 3D fast disturbing phase gradient flipping and restoring 3D-FSPGR. the scanning sequence of fMRI was used in T2-plane echo image-gradient echo echo EPI-GRE.After the scan was completed, the data was preprocessed by "DPARSF" software, and the hypothalamus was selected as the seed area of functional connection. Based on the t-test of two independent samples in "REST" software, the local consistency, the low frequency fluctuation amplitude and the functional connection are used as the evaluation index. To compare the difference and correlation between IBS group and healthy control group under resting condition. Results compared with the healthy control group, the decrease of ReHo in IBS patients included bilateral cingulate gyrus, bilateral frontal lobe and left island lobe. The increased areas included the right frontal orbital gyrus, bilateral temporal lobe, bilateral occipital lobe and bilateral posterior cerebellar lobe (two independent samples of t test P 0.001, and the comparison of ALFF values after correction.) compared with the healthy control group, the areas in which the rest state of the ALFF group showed ALFF enhancement included the bilateral thalamus. In the right hippocampus, the left hippocampal gyrus, the bilateral inferior parietal gyrus, the right anterior cerebellar lobe, the cerebellar vermis, the bilateral inferior occipital gyrus, the bilateral frontal lobe and the left anterior cingulate gyrus. Comparison of functional connections in the thalamus of the right insular lobe (two independent samples (P0.001, corrected): the connections of the posterior cingulate gyrus and the bilateral anterior thalamic nuclei in the IBS group were enhanced compared with those in the healthy control group. The left cuneiform junction was weakened (two independent samples of t-test, P0.01, corrected). Conclusion: there are abnormal brain regions associated with brain pain management and dysfunction of brain network in patients with IBS at rest, which may be involved in the central pathogenesis of IBS. It is worth studying in depth.
【学位授予单位】：浙江大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R445.2;R574.4

【相似文献】