肺癌短期重复扫描ADC值和IVIM参数值的测量可重复性

发布时间：2018-03-24 20:18

本文选题：肺肿瘤　切入点：磁共振成像　出处：《放射学实践》2017年11期

【摘要】：目的:前瞻性评估肺癌短期重复扫描的ADC值及体素内不相干运动(IVIM)参数值的测量可重复性。方法:27个肺癌患者(27个病灶)进行2次自由呼吸DWI(b=0,300,800s/mm~2)及IVIM(10个b值,b=0~1000s/mm~2)扫描(间隔30~60min)。2名独立测量者分别在ADC图、IVIM图上通过勾勒病灶获得ADC均值和D、D*、f值。采用配对样本t检验(正态分布)或Wilcoxon检验(非正态分布)比较重复测量、不同测量者和重复扫描的误差。各参数值的测量者内可重复性、测量者间一致性以及两次扫描的测量可重复性采用组内相关系数(ICC)、组间变异系数(WCV)和BlandAltman法评价。结果:重复测量和重复扫描所得ADC均值、IVIM参数值差异均无统计学意义(P0.05)。所有参数显示出好的测量者内可重复性和测量者间一致性,除了D*(WCV㧐30%)。重复扫描D值的可重复性最佳(ICC为0.905、0.883,WCV为7.63%、8.46%),ADC值的可重复性较好(ICC为0.829、0.823,WCV为10.65%、11.13%),而D*和f的可重复性相对较差(ICC为0.639~0.802;WCV为39.50%~58.14%)。结论:当运用DWI或IVIM来监测肺癌疗效时,若ADC值、D、D*和f值的变化分别小于21.81%、16.58%、113.95%和84.77%,则很可能是由测量误差引起。需要改进IVIM扫描技术和后处理算法,提高D*和f的测量可重复性。
[Abstract]:Objective: to prospectively evaluate the reproducibility of ADC and IVIMI parameters of short-term repeated scanning of lung cancer. Methods: 27 patients with lung cancer (27 lesions) underwent two free breathing DWIIBX 0300800s / mmmm2 and IVIMI (10 b values 0 1000smm2). The mean value of ADC and the value of ADC were obtained by delineating the lesions on the ADC diagram. The paired sample t-test (normal distribution) or Wilcoxon test (non-normal distribution) were used to compare the repeated measurements. Errors in different measurements and repeated scans. Repeatability of measurements for each parameter value, The consistency of measurement and the repeatability of two scans were evaluated by intragroup correlation coefficient (ICCV) and BlandAltman method. Results: there was no significant difference in the ADC mean value of IVIM between repeated measurements and repeated scans. All parameters show good intra-measurement repeatability and consistency between measurements. Except for DX WCVS? The best reproducibility of D value for repeated scanning was 0.9050.883WCV 7.630.46A / A = 0.829 / 0.823WCV = 10.65 / 11.13C, while the relative poor reproducibility of D * and f was 0.6390.802WCV = 39.500.802WCV = 39.5058.140.Conclusion: when DWI or IVIM were used to monitor the curative effect of lung cancer, the relative reproducibility of D value was 0.9050.802WCV = 39.500.802WCV = 58.140.Conclusion: when DWI or IVIM are used to monitor the curative effect of lung cancer, If the ADC values are less than 21.81% and 16.58% and 84.77%, respectively, they may be caused by measurement errors. It is necessary to improve the IVIM scanning technique and post-processing algorithm to improve the repeatability of D * and f measurements.
【作者单位】：南通大学第二附属医院;盐城市第一人民医院放射科;苏州市立医院影像科;
【分类号】：R445.2;R734.2

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