磁共振波谱及扩散加权成像在糖尿病患者脑损伤评估中的应用

发布时间：2018-03-24 21:32

本文选题：糖尿病　切入点：磁共振波谱　出处：《山东医药》2017年44期

【摘要】：目的探讨磁共振波谱(MRS)及扩散加权成像(DWI)评估糖尿病患者脑损伤的价值。方法选择单纯2型糖尿病患者30例(糖尿病组)及同期体检健康者30例(对照组),均行3.0T MR常规扫描及MRS、DWI,测量双侧半卵圆中心的ADC值、eADC值、N-乙酰天门冬氨酸与肌酸比值(NAA/Cr)、胆碱复合物与肌酸比值(Cho/Cr)及N-乙酰天门冬氨酸与胆碱复合物比值(NAA/Cho),并分析糖尿病组各指标的相关性。结果糖尿病组双侧半卵圆中心ADC值、左侧半卵圆中心Cho/Cr均高于对照组,双侧半卵圆中心e ADC值、NAA/Cr与NAA/Cho均低于对照组(P均0.05)。两组右侧半卵圆中心Cho/Cr比较无统计学差异(P0.05)。糖尿病组双侧半卵圆中心ADC值、eADC值与NAA/Cr、Cho/Cr、NAA/Cho均无显著相关性(P均0.05)。结论 MRS及DWI可有效显示糖尿病患者脑部功能区的代谢状况及脑组织水分子改变,其相关参数改变可为糖尿病患者脑损伤评估提供量化依据。
[Abstract]:Objective to explore the magnetic resonance spectroscopy (MRS) and diffusion weighted imaging (DWI) to assess the value of brain damage in diabetic patients. Methods 30 cases of simple type 2 diabetic patients (diabetic group) and 30 cases of healthy volunteers (control group) underwent conventional 3.0T scan, MR and MRS, DWI were measured, semioval the center of the ADC value, eADC value, N- acetyl aspartic acid and creatine ratio (NAA/Cr), choline and creatine ratio (Cho/Cr) and N- acetyl aspartic acid and choline ratio (NAA/Cho), and to analyze the correlation between diabetes group index. Results bilateral centrum semiovale ADC value. On the left side of the center of a circle of Cho/Cr were higher than the control group, bilateral semioval center e ADC, NAA/Cr and NAA/Cho were lower than the control group (P < 0.05). The two groups on the right side of the centrum semiovale Cho/Cr had no significant difference (P0.05). The diabetic group of bilateral semioval center ADC value, eADC value and NAA There was no significant correlation between /Cr, Cho/Cr and NAA/Cho (P = 0.05). Conclusion MRS and DWI can effectively show the metabolic status of brain functional areas and changes of water molecules in brain tissue of diabetic patients, and the change of related parameters can provide quantitative basis for the assessment of brain injury in diabetic patients.

【作者单位】：三峡大学医学院;宜昌市第一人民医院;
【分类号】：R445.2;R587.2

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