原发性失眠全脑度中心度的改变

发布时间：2018-03-27 19:52

本文选题：静息态功能磁共振　切入点：原发性失眠　出处：《中山大学学报(医学科学版)》2017年03期

【摘要】：【目的】基于静息态功能磁共振成像技术(fMRI),利用度中心度(DC)分析方法探讨原发性失眠(PI)患者静息态下脑神经网络功能连接的异常属性,找寻原发性失眠相关神经机制的影像学证据。【方法】对59例PI患者及47例年龄、性别、受教育程度均匹配的健康对照组进行静息状态下的功能磁共振成像扫描,经预处理和后处理计算出全脑DC值图,采用双样本t检验进行组间比较,分别检测PI组与NC组间DC分布图间的统计学差异。【结果】对比正常对照组,PI患者DC值明显降低的脑区主要包括双侧额中回(MFG)、双侧前扣带回(ACG)及右侧脑岛(Insula)等区域。DC值明显增加的脑区主要包括右侧颞叶中回(MTG)及左侧楔叶(CUN)等脑区(P0.05)。【结论】基于静息态功能MRI数据的DC分析观察到PI患者在脑区间功能连接改变,DC作为一种新的基于体素水平描述脑网络属性的方法,可能对理解PI神经机制及观察其脑网络属性的改变提供了一个新视角。
[Abstract]:[objective] based on the resting functional magnetic resonance imaging (fMRI) technique and using the degree of centrality (DCV) analysis method, the abnormal properties of functional connections of neural networks in patients with primary insomnia were studied. To find the imaging evidence of neural mechanism related to primary insomnia. [methods] 59 patients with Pi and 47 healthy controls matched with age, sex and education were examined by functional magnetic resonance imaging (fMRI). After preprocessing and post-processing, the whole brain DC value map was calculated, and the comparison between groups was carried out by double sample t-test. The difference of DC distribution between Pi group and NC group was detected respectively. [results] compared with the normal control group, the decrease of DC value in patients with Pi mainly included bilateral middle frontal gyrus MFGG, bilateral anterior cingulate gyrus (ACGG) and right islet Insula). The significant increase in DC value mainly includes the right temporal lobe middle gyrus (MTG) and left cuneiform (CUN). [conclusion] DC analysis based on resting functional MRI data shows that the change of functional junctions in Pi patients is a new method. A method for describing brain network attributes based on voxel level, It may provide a new perspective for understanding Pi neural mechanism and observing the changes of brain network properties.
【作者单位】：广东省第二人民医院;
【基金】：广州市科技计划立项项目(201607010056)
【分类号】：R740

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