基于脑皮层厚度分析在肝性脑病结构改变的研究

发布时间：2018-03-27 20:29

本文选题：皮层厚度　切入点：肝性脑病　出处：《临床放射学杂志》2017年02期

【摘要】：目的探讨不同阶段肝性脑病(HE)患者皮层厚度改变情况。方法搜集22例症状型HE(SHE)患者(SHE组)、20例轻微型HE(MHE)患者(MHE组)、25例无肝性脑病肝硬化患者(NMHE组)和27例健康对照者(HC组)行MRI扫描并获取T_1-3D全脑高分辨结构图,采用Freesurfer软件计算皮层厚度,对比分析患者组与HC组皮层厚度差异及SHE组皮层厚度与血氨的相关性分析。结果对比HC组,SHE组在左侧岛环状沟上份、中后扣带回、左侧楔前叶、左侧侧副沟和舌沟、右侧中央前沟下份、右侧颞上回、右侧侧副沟和舌沟区域皮层厚度降低;MHE组在右侧中央前沟下份区域皮层厚度降低;NMHE组在左侧额下沟区域皮层厚度降低(P0.05)。结论SHE组、MHE及NMHE患者大脑多个区域皮层厚度存在异常,并随着HE发展进程中表现出皮层改变区域逐渐增多趋势。
[Abstract]:Objective to investigate the changes of cortical thickness in patients with hepatic encephalopathy (HEH) at different stages. Methods 22 patients with symptomatic HESHEE, 20 patients with mild HEMHEE) and 25 patients with non hepatic encephalopathy cirrhosis (NMHE) and 27 healthy controls were collected. The MRI scan was performed and the T1-3D high resolution structure of the whole brain was obtained. The cortical thickness was calculated by Freesurfer software, and the cortical thickness difference between the patient group and HC group, and the correlation between cortex thickness and blood ammonia in SHE group were analyzed. Results the left island circumferential sulcus, middle posterior cingulate gyrus, left anterior cuneiform lobe were compared in the left island ring sulcus of HC group. Left lateral accessory sulcus and lingual sulcus, right precentral sulcus inferior portion, right superior temporal gyrus, right superior temporal gyrus, The cortical thickness of the right lateral accessory sulcus and the lingual sulcus decreased in the right precentral sulcus and the left subfrontal sulcus in the NMHE group. Conclusion in the SHE group, the cortical thickness of multiple regions of the brain is abnormal in the patients with MHE and NMHE, and the cortical thickness of the left subfrontal sulcus in the NMHE group is lower than that in the NMHE group. And with the development of HE showed that the cortical changes in the region gradually increased.
【作者单位】：重庆医科大学附属第二医院放射科;西南大学心理学部;
【基金】：国家自然科学基金面上项目(编号:81071126)
【分类号】：R445.2;R575.3

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