胃癌术前CT强化率、灌注参数与血清肿瘤标志物含量、肿瘤病灶增殖分子表达的关系

发布时间：2018-03-28 06:53

  本文选题：胃癌　切入点：计算机断层扫描　出处：《海南医学院学报》2017年06期

【摘要】：目的:探讨胃癌术前CT强化率、灌注参数与血清肿瘤标志物含量、肿瘤病灶增殖分子表达的关系。方法:收集榆林市第二医院收治的胃癌患者68例作为观察组,根据肿瘤分期分为早中期胃癌组41例、晚期胃癌组27例;取同期在本院就诊被证实为胃良性病变的患者50例作为胃良性病变组。采用CT扫描检测三组患者的CT强化率、灌注参数,采用酶联免疫吸附法(ELISA)检测血清肿瘤标志物含量,采用RT-PCR法检测病灶组织增殖基因mRNA表达量。结果:晚期胃癌组的CER、AF、BV、CL水平高于早中期胃癌组、胃良性病变组(P0.05);晚期胃癌组的血清CA72-4、CA19-9、CA125、CEA含量高于早中期胃癌组、胃良性病变组(P0.05);晚期胃癌组的组织CADM1、miRNA-34a、Cystatin M mRNA表达量低于早中期胃癌组、胃良性病变组,Survivin、I2PP2A mRNA表达量高于早中期胃癌组、胃良性病变组(P0.05)。经Pearson检验发现,胃癌患者的CT强化率、灌注参数与血清肿瘤标志物含量、肿瘤病灶增殖分子表达量存在直接相关关系。结论:胃癌术前CT强化率、灌注参数与肿瘤恶性程度直接相关,可作为远期肿瘤诊断及恶性程度判断的可靠手段。
[Abstract]:Objective: to investigate the relationship between CT enhancement rate, perfusion parameters and serum tumor markers and the expression of proliferative molecules in gastric cancer before operation. Methods: 68 patients with gastric cancer treated in the second Hospital of Yulin City were collected as observation group. According to tumor staging, 41 cases of early and middle stage gastric cancer group and 27 cases of advanced gastric cancer group were divided into three groups, 50 cases of gastric benign lesions were confirmed as gastric benign lesions in our hospital at the same time. Ct scanning was used to detect the enhancement rate of CT in the three groups. The serum tumor markers were detected by Elisa and the expression of proliferative gene mRNA was detected by RT-PCR method. Results: the level of RT-PCR in advanced gastric cancer group was higher than that in early and middle stage gastric cancer group. The level of serum CA72-4, CA19-9, CA125A, CADM1-miRNA-34aCystatin M mRNA in advanced gastric cancer group was higher than that in early and middle stage gastric cancer group, and the expression of survivin I2PP2A mRNA in gastric benign lesion group was higher than that in early metaphase gastric cancer group, while the expression of CADM1-miRNA-34aCystatin M mRNA in advanced gastric cancer group was lower than that in early and middle stage gastric cancer group, and the expression of CA72-4, CA19-9 and CA125A in advanced gastric cancer group was higher than that in early and middle stage gastric cancer group. Pearson test showed that there was a direct correlation between CT enhancement rate, perfusion parameters and serum tumor markers and the expression of proliferative molecules in gastric cancer. Conclusion: the CT enhancement rate of gastric cancer before operation is significantly higher than that of control group. The perfusion parameters are directly related to the malignant degree of the tumor and can be used as a reliable means for the long term diagnosis and the judgement of the malignant degree.
【作者单位】： 陕西省榆林市第二医院影像中心;
【分类号】：R735.2
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本文编号：1675221