血压正常2型糖尿病患者大脑微结构改变的VBM及TBSS研究

发布时间：2018-03-30 23:11

本文选题：型糖尿病　切入点：脑白质　出处：《神经解剖学杂志》2017年01期

【摘要】：目的:基于纤维束示踪空间统计分析(TBSS)研究大脑扩散张量成像(DTI)图像,观察血压正常2型糖尿病(T2DM)患者脑白质微结构的改变,并探讨双侧大脑半球间的脑白质改变方法:本研究纳入20名血压正常的T2DM患者及20名年龄、性别匹配的正常对照。采用3.0T磁共振扫描仪采集大脑结构像和DTI数据,应用基于体素的形态学分析(VBM)和TBSS方法比较两组受试者间的大脑体积,白质各向异性分数(FA)和平均扩散系数(MD)值的差异,以及两组受试者左右侧大脑半球DTI参数比值的差异。结果:与正常对照相比,血压正常的T2DM患者大脑体积未见显著减小(P0.05);大脑白质完整性广泛受损,尤以胼胝体膝部、左侧内囊前肢、辐射冠前上部、扣带束及上额-枕束为著;右侧上辐射冠、后辐射冠、扣带束及上纵束FA值和MD值均有改变(P0.05);双侧大脑半球上辐射冠MD值升高,以左侧升高更为显著(P0.05)。结论:血压正常的T2DM患者双侧大脑半球白质微结构广泛损伤,尤以左侧为著,TBSS分析有助于早期检出上述改变。
[Abstract]:Objective: to study the brain diffusion imaging (DTI) images of patients with normal blood pressure type 2 diabetes mellitus (T2DM) by using TBSS-based tracer space analysis (TBSS), and to observe the changes of white matter microstructure in patients with normal blood pressure type 2 diabetes mellitus (T2DM).Methods: 20 T2DM patients with normal blood pressure and 20 age-matched normal controls were included in this study.Brain structure images and DTI data were collected by 3.0T magnetic resonance scanner. The difference of brain volume, white matter anisotropy fraction (FAA) and mean diffusion coefficient (MDR) between the two groups were compared by using morphologic analysis based on voxel and TBSS method.And the difference of the ratio of DTI parameters between the left and right cerebral hemispheres between the two groups.Results: compared with the normal controls, the cerebral volume of T2DM patients with normal blood pressure was not significantly decreased (P 0.05), and the white matter integrity was extensively impaired, especially in the genu of corpus callosum, the anterior limb of the left internal capsule, the upper anterior coronal radiation, the cingulate band and the superior frontal-occipital bundle.The values of FA and MD of the right upper radiative crown, posterior radiative crown, cingulate band and upper longitudinal beam were all changed (P 0.05), and the MD value of the bilateral cerebral hemisphere was higher than that of the left side (P 0.05).Conclusion: T2DM patients with normal blood pressure have extensive damage of white matter microstructure in bilateral cerebral hemispheres, especially in the left side, which is helpful for early detection of these changes.
【作者单位】：第四军医大学唐都医院放射科;
【基金】：国家自然科学基金(81471636)
【分类号】：R587.2;R445.2

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