儿童化脓性脑膜炎病原菌分布及其耐药性分析

发布时间：2018-03-31 15:09

本文选题：化脓性脑膜炎　切入点：病原菌　出处：《临床儿科杂志》2017年05期

【摘要】：目的探讨儿童化脓性脑膜炎病原菌分布及其对抗菌药物的敏感性。方法回顾分析2010年1月-2014年12月收治的54例化脓性脑膜炎患儿的脑脊液涂片及培养结果。结果 54株病原菌以革兰阳性球菌为主共36株,革兰阴性杆菌17株,疑似脑膜炎奈瑟菌1例。革兰阳性球菌中以肺炎链球菌为主共31株,革兰阴性杆菌中以大肠埃希菌为主。革兰阳性球菌中61.3%对青霉素敏感,90%以上对头孢曲松、头孢吡肟敏感,对美洛培南敏感率83.3%,对阿奇霉素耐药达94.7%,18株对苯唑西林耐药58.1%;在革兰阴性杆菌中,对氨苄西林舒巴坦敏感率60%,对头孢他啶敏感率71.4%,对头孢曲松敏感率57.1%,对头孢吡肟敏感率66.6%。结论济南地区儿童化脓性脑膜炎病原菌以肺炎链球菌和大肠埃希菌为主。
[Abstract]:Objective to investigate the distribution of pathogenic bacteria in children with suppurative meningitis and their sensitivity to antimicrobial agents. Methods the cerebrospinal fluid smears of 54 children with suppurative meningitis from January 2010 to December 2014 were retrospectively analyzed. There were 36 strains of Gram-positive cocci in 54 strains. There were 17 Gram-negative bacilli and 1 suspected Neisseria meningitidis. Among the gram-positive cocci, 31 were Streptococcus pneumoniae. Among Gram-negative bacilli, Escherichia coli was the main bacteria. 61.3% of Gram-positive cocci were sensitive to penicillin, more than 90% were sensitive to ceftriaxone and cefepime, and 61.3% were sensitive to ceftriaxone and cefepime. The sensitivity to melopenem was 83.3%, and the resistance to azithromycin was 94.77.18 strains were resistant to oxacillin 58.1%; in Gram-negative bacilli, The sensitivity to ampicillin sulbactam was 60%, to ceftazidime 71.4, to ceftriaxone 57.1, and to cefepime 66.6. Conclusion Streptococcus pneumoniae and Escherichia coli are the main pathogens of suppurative meningitis in Jinan area.
【作者单位】：济南市儿童医院;济南市妇幼保健院儿科;
【分类号】：R446.5;R742.9

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