超声造影评价乳腺癌边缘带增殖活性与Ki-67相关性研究

发布时间：2018-04-05 10:39

本文选题：乳腺癌　切入点：超声造影　出处：《中国超声医学杂志》2017年10期

【摘要】：目的应用超声造影技术评价乳腺癌不同感兴趣区灌注情况,并研究Ki-67阳性病灶增强模式及分析癌边缘带灌注参数与Ki-67不同表达的相关性。方法收集乳腺癌患者60例,经超声造影及QLAB软件对不同感兴趣区进行时间-强度曲线分析并进行比较。同时对Ki-67不同表达病灶的增强模式和其与癌边缘带灌注参数进行相关性分析。结果乳腺癌边缘带相对于其他感兴趣区多呈快进慢退、高增强。Ki-67表达阳性乳腺癌病灶多呈快进慢退、高增强,造影剂分布不均匀,造影后病灶范围多数扩大。在研究癌边缘带与Ki-67相关性得出其与峰值强度及曲线下面积呈正相关,与达峰时间呈负相关。结论乳腺癌边缘带为乳腺癌组织增殖最活跃的区域,Ki-67的阳性表达使乳腺癌更具有侵袭性。
[Abstract]:Objective to evaluate the perfusion status of different regions of interest in breast cancer by contrast-enhanced ultrasonography, to study the enhancement pattern of Ki-67 positive lesions and to analyze the correlation between the perfusion parameters of the marginal zone and the expression of Ki-67.Methods 60 patients with breast cancer were analyzed and compared by contrast-enhanced ultrasound and QLAB software.At the same time, the enhancement patterns of different Ki-67 expression lesions and their correlation with the perfusion parameters of the marginal zone were analyzed.Results compared with other regions of interest, the marginal zone of breast cancer showed fast progression and slow regression. The lesions of high enhancement. Ki-67 positive breast cancer showed fast progression and slow regression, high enhancement, uneven distribution of contrast media, and most of the lesions were enlarged after angiography.The correlation between the Ki-67 and the marginal zone was found to be positively correlated with the peak intensity and area under the curve, and negatively correlated with the peak time.Conclusion the positive expression of Ki-67 in the marginal zone of breast cancer is the most active proliferative region of breast cancer, which makes the breast cancer more invasive.
【作者单位】：新疆医科大学第一附属医院腹部超声诊断科;
【分类号】：R445.1;R737.9

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