肠屏障损伤与肠源性感染

发布时间：2018-04-05 18:17

本文选题：肠屏障　切入点：肠源性感染　出处：《肠外与肠内营养》2017年02期

【摘要】：正肠源性感染(gut-derived infection)是严重创(烧)伤、大手术、失血性休克、重症急性胰腺炎等危重症病人死亡的主要原因之一~([1])。在上述病理条件下,肠道细菌可通过受损的肠黏膜侵入外周血和远隔器官,形成细菌易位,诱发全身性炎症反应、脓毒症和多器官功能障碍综合征(MODS),导致病人死亡~([2])。肠屏障(intestinal barrier)主要由肠上皮屏障、肠道微生物屏障和黏膜免疫屏障组成。以往细
[Abstract]:Positive enterogenous infection (IBI) is one of the main causes of death in critically ill patients, such as severe burn, major operation, hemorrhagic shock, severe acute pancreatitis and so on.Under the above pathological conditions, intestinal bacteria can invade peripheral blood and distant organs through damaged intestinal mucosa, form bacterial translocation, induce systemic inflammatory reaction, sepsis and multiple organ dysfunction syndrome, and lead to death of patients ([2]).Intestinal barrier is mainly composed of intestinal epithelial barrier, intestinal microbial barrier and mucosal immune barrier.Past detail
【作者单位】：南京大学医学院附属金陵医院(南京军区南京总医院)解放军普通外科研究所;
【分类号】：R459.7

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