采用血管内超声弹性成像技术分析动脉粥样硬化斑块负荷与面积应变的关系

发布时间：2018-04-05 22:20

  本文选题：血管内超声检查　切入点：弹性成像技术　出处：《中国医学影像技术》2017年10期

【摘要】：目的采用血管内超声弹性成像技术评价斑块负荷(PB)与面积应变(AS)的关系。方法对40只雄性纯种新西兰兔全程高脂饲料喂养。第2周末行腹主动脉球囊拉伤术。第12周末行腹主动脉血管内超声检查,对每只动物选择两个等回声斑块,采集不少于3个心动周期的原位血管内超声图像,选择舒张末期连续2帧原位图像,构建血管内超声弹性图。测量并计算血管外弹力膜面积(EEMarea)、血管腔面积(Lumenarea)、斑块面积(PA)、PB、血管外弹力膜体积(EEMvolume)、血管腔体积(Lumenvolume)、斑块体积(PV)、斑块体积负荷(PVB)、斑块最大厚度(Tmax)、斑块最小厚度(Tmin)、斑块偏心指数(EI)、血管重构指数(RI)及AS。根据PB不同,将斑块分为低负荷斑块组(PB≤40%)和高负荷斑块组(PB40%),并对两组间以上参数的差异、斑块形态学和力学参数的关系等进行统计学分析。结果两组的PA、PV、PB、PVB、Tmin、Tmax、Lumenarea、Lumenvolume、EI差异均有统计学意义(P均0.01)。经逐步多元线性回归分析,回归方程为:Y∧=-6.921+10.430 X1+12.207 X2(Y∧:AS;X1:EI;X2:PB;R2=0.272,P0.001)。在矫正偏心指数对AS的影响后,低负荷斑块组的AS明显小于高负荷斑块组(P=0.010)。结论动脉粥样硬化斑块的负荷对斑块力学稳定性有影响。高负荷斑块较低负荷斑块更易受损。
[Abstract]:Objective to evaluate the relationship between plaque load and area strain (ASA) by intravascular ultrasound elastography.Methods Forty male pure New Zealand rabbits were fed with high fat diet.Abdominal aortic balloon tension was performed at the end of the second week.At the end of the 12th week, the abdominal aorta was examined by intravascular ultrasound. Two isoechoic plaques were selected for each animal. In situ intravascular ultrasound images of not less than 3 cardiac cycles were collected, and two consecutive in situ images at the end of diastole were selected.Intravascular ultrasound elastography was constructed.The index of EI, the index of vascular remodeling, the index of vascular remodeling, and the ASs.According to PB, plaques were divided into low load plaque group (PB 鈮，

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