血清γ-谷氨酰转肽酶与2型糖尿病及并发糖尿病肾病的相关性研究

发布时间：2018-04-07 16:38

本文选题：谷氨酰转移酶　切入点：型糖尿病　出处：《中国实验诊断学》2017年01期

【摘要】：目的探讨血清中γ-谷氨酰转肽酶(GGT)与单纯2型糖尿病(T2DM)及糖尿病性肾病(DN)的相关性。方法收集健康者(对照组)54例、2型糖尿病患者(T2DM组)73例和糖尿病肾病患者(DN组)73例的相关资料,并测定其血清中γ-谷氨酰转肽酶(GGT)、谷丙转氨酶(ALT)、谷草转氨酶(AST)、超氧化物岐化酶(SOD)、谷胱甘肽(GSH)、8-羟基脱氧鸟苷(8-OHdG)、肌酐(Cre)、尿素氮(BUN)、尿酸(UA)、空腹血糖(FPG)含量以及24小时尿蛋白定量(24hU-Pro),并进行比较分析。结果与健康对照组相比,T2DM组GGT、ALT、AST水平和FPG明显升高(P0.05),DN组的各项观察指标均明显高于健康对照组(P0.05);与T2DM组相比,DN组ALT、AST水平无明显差异(P0.05),而SOD、GSH明显降低(P0.05),其它指标均明显升高(P0.05)。T2DM患者血清GGT水平与FPG、AST、ALT具有相关性,其中与FPG关系最密切(r=0.927);DN患者GGT水平与所有检测指标均具有相关性,其中与24hU-Pro关系最密切(r=0.973)。结论血清GGT与T2DM、DN有一定相关性,可能是导致这两种疾病发生的危险因素。
[Abstract]:Objective to investigate the relationship between serum 纬 -glutamyl transpeptidase (GGTT) and type 2 diabetes mellitus (T2DM) and diabetic nephropathy (DN).Methods the data of 73 healthy subjects (control group, 54 patients with type 2 diabetes mellitus) and 73 patients with diabetic nephropathy (DN group, n = 73) were collected.The protein was quantified and compared with that of 24 h U-ProN.Results compared with the healthy control group, the levels of GGT, alt, AST and FPG in the T2DM group were significantly higher than those in the healthy control group (P 0.05), and the levels of alt in the T2DM group were not significantly different from those in the T2DM group, while the level of FPG in the T2DM group was significantly lower than that in the control group, and the other indexes were all clear.The level of serum GGT in patients with P0.05U 路T2DM was significantly higher than that in patients with P0.05U. T2DM, and there was a correlation between serum GGT level and alt.The level of GGT in patients with DN was most closely related to FPG. The level of GGT was correlated with all the indexes, and the most closely related to 24hU-Pro was 0.973%.Conclusion Serum GGT is associated with T 2 DMN DN, which may be the risk factor of these two diseases.
【作者单位】：吉林省人民医院检验科;吉林大学公共卫生学院;吉林大学基础医学院生物化学教研室;
【基金】：吉林省卫生计生青年科研课题(2014Q009)
【分类号】：R587.2;R692.9;R446.1

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