超声引导下穿刺细胞检测Galectin-3和CK19在良、恶性甲状腺滤泡性肿瘤的表达差异

发布时间：2018-04-08 20:16

  本文选题：甲状腺肿瘤　切入点：半乳糖凝集素　出处：《中国临床医学影像杂志》2017年01期

【摘要】：目的:探讨超声引导下穿刺细胞检测Galectin-3和CK19在良、恶性甲状腺滤泡性肿瘤的表达差异。方法 :选取甲状腺滤泡状癌(FTC)患者34例分为FTC组,甲状腺滤泡性腺瘤(FA)40例分为FA组。检测患者的超声引导下细针穿刺细胞学检查(FNAC)标本和病理组织的Galectin-3、CK19表达,分析两组FNAC标本的Galectin-3、CK19表达情况;以病理组织的Galectin-3和CK19表达情况为标准,分析FNAC标本表达Galectin-3和CK19的敏感性、特异性和准确性。比较Galectin-3、CK19与FTC患者的临床参数资料的关系。结果 :Galectin-3、CK19在FTC组和FA组的表达有显著差异(Galectin-3:Z=-4.478,P=0.000;CK19:Z=-2.307,P=0.021);FNAC标本检测CK19、Galectin-3表达的敏感性、特异性、准确性分别为85.7%、76.3%、81.3%,和84.7%、91.2%、87.5%。Galectin-3的表达在FTC患者的不同性别、年龄、肿瘤直径之间无明显差异(P0.05);而Galectin-3阳性率在有淋巴结转移(93.3%)和TNMⅢ+Ⅳ分期(100%)的患者比无淋巴结转移(63.2%)和TNMⅠ+Ⅱ分期(66.7%)患者的高,差异有统计学意义(分期:T=4.359,P=0.037;淋巴结转移:T=4.242,P=0.039);CK19的表达在这些临床参数之间均无明显差异(P0.05)。结论:FTC患者的FNAC标本检测Galectin-3和CK19的表达明显高于FA患者,可为临床工作用鉴别诊断FTC和FA提供一定的协助作用。
[Abstract]:Objective: to investigate the expression of Galectin-3 and CK19 in benign and malignant thyroid follicular tumors.Methods: 34 cases of thyroid follicular carcinoma were divided into FTC group and 40 cases of thyroid follicular adenoma were divided into FA group.To detect the expression of Galectin-3C19 in the specimens of FNAC and pathological tissues under the guidance of ultrasound, and to analyze the expression of Galectin-3CK-19 in the two groups of FNAC, the expression of Galectin-3 and CK19 in the pathological tissues was taken as the standard.The sensitivity, specificity and accuracy of FNAC expression of Galectin-3 and CK19 were analyzed.To compare the relationship between Galectin-3 P CK19 and clinical data of FTC patients.The positive rate of Galectin-3 was higher in patients with lymph node metastasis (93. 3%) and TNM 鈪，

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