中老年人血清维生素D水平与代谢综合征的相关性研究

发布时间：2018-04-09 20:40

本文选题：中年人　切入点：老年人　出处：《中国全科医学》2017年16期

【摘要】：目的分析中老年人血清维生素D(Vit D)水平与代谢综合征(MS)的相关性,探讨Vit D在MS发病中的作用。方法选取2014年7月—2016年2月在安徽省铜陵市人民医院住院和门诊就诊的中老年(年龄45岁及以上)MS患者519例为MS组。另外选取2015年10—12月年龄45岁及以上无MS的社区体检人员510例为对照组。测定身高、体质量、血压[收缩压(SBP)、舒张压(DBP)];检测空腹血糖(FPG)、总胆固醇(TC)、三酰甘油(TG)、高密度脂蛋白胆固醇(HDL-C)、低密度脂蛋白胆固醇(LDL-C)、载脂蛋白A1(Apo-A1)、载脂蛋白B100(Apo-B100)、脂蛋白a[Lp(a)]、非酯化脂肪酸(FFA)、同型半胱氨酸(HCY)、血钙、血磷、Vit D、甲状旁腺激素(PTH)及空腹胰岛素(FINS);计算BMI、稳态模式评估胰岛素抵抗指数(HOMA-IR)、钙磷乘积。结果两组性别、年龄、身高、体质量、BMI、TC、TG、HDL-C、LDL-C、FFA、血钙、血磷、钙磷乘积比较,差异无统计学意义(P0.05);MS组SBP、DBP、Apo-B100、Lp(a)、HCY、FPG、FINS、HOMA-IR高于对照组,Apo-A1、Vit D、PTH低于对照组,差异有统计学意义(P0.05)。两组Vit D水平分布比较,差异有统计学意义(P0.05)。不同Vit D水平的MS患者性别、HOMA-IR、PTH比较,差异有统计学意义(P0.05);不同Vit D水平的MS患者年龄、身高、体质量、BMI、SBP、DBP、TC、TG、HDL-C、LDL-C、Apo-A1、Apo-B100、LP(a)、FFA、HCY、FPG、FINS、血钙、血磷、钙磷乘积比较,差异无统计学意义(P0.05)。Vit D与性别、BMI、DBP、Apo-B100、HCY、FPG、HOMA-IR、PTH呈负相关(P0.05),与SBP、LDL-C呈直线正相关(P0.05)。结论MS患者常表现为高血压、高血糖、高血脂等代谢紊乱综合征,血清Vit D水平与血压、血糖、胰岛素抵抗等存在相关性,Vit D水平的降低可能是MS发病的机制之一。
[Abstract]:Objective to analyze the correlation between serum vitamin D vitamin D (Vit D) levels and metabolic syndrome (MS) in middle-aged and elderly people and to explore the role of Vit D in the pathogenesis of MS.Methods from July 2014 to February 2016, 519 middle-aged and elderly patients with MS aged 45 years or older were selected as MS group in Tongling people's Hospital of Anhui Province.In addition, 510 community health examiners aged 45 years and over from October to December 2015 were selected as control group.Measuring height and body mass,Type I cysteine HCYA, blood calcium,Vit D (PTH) and fasting insulin (FINSN) were calculated, insulin resistance index (HOMA-IRN) and calcium phosphorus product were evaluated by steady-state model.The difference of Vit D level between the two groups was statistically significant (P 0.05).There was no significant difference between P0.05U. Vit D and BMIB BMIB BPU Apo-B100 HCYFPG HOMA-IRT PTH. There was a negative correlation (P0.05) and a linear positive correlation (P0.05) between Vit D and LDL-C of SBP.Conclusion MS patients often present with metabolic disorders such as hypertension, hyperglycemia and hyperlipidemia. The decrease of serum Vit D level and blood pressure, blood glucose and insulin resistance may be one of the pathogenesis of MS.
【作者单位】：安徽省铜陵市人民医院检验科;安徽省铜陵市人民医院内分泌科;
【基金】：铜陵市卫计委基金资助项目(卫科研[2015]7号)
【分类号】：R446.1;R589

【相似文献】