持续性非卧床腹膜透析患者的临床特征及影响腹膜转运功能的相关因素

发布时间：2018-04-11 08:53

本文选题：持续性非卧床腹膜透析 + 腹膜转运　；参考：《中南大学学报(医学版)》2017年06期

【摘要】：目的:观察不同腹膜转运类型的持续性非卧床腹膜透析(continuous ambulatory peritoneal dialysis,CAPD)患者的临床特征,探讨影响腹膜转运功能的相关因素。方法:回顾性总结158例CAPD患者的临床资料,根据腹膜平衡试验评价患者的腹膜转运功能并将其分为高平均转运+高转运组(A组,n=84)和低平均转运+低转运组(B组,n=74),并对两组患者的人口学资料、临床生物化学指标以及心血管并发症情况进行比较;应用logistic回归分析寻找影响患者腹膜转运功能的相关因素。结果:B组患者血清白蛋白(albumin,ALB)水平显著高于A组(P0.05)。A组患者的4 h透析液肌酐与血肌酐浓度的比值(dialysate/plasma creatinine,D/Pcr)、超敏C反应蛋白(high-sensitivity C-reactive protein,hsCRP)、体重指数(body mass index,BMI)及心血管并发症的发生率均显著高于B组(均P0.05)。相关分析显示:D/Pcr与BMI,hs-CRP和心血管并发症呈正相关(分别r=0.179,0.373和0.426,均P0.05);与ALB呈负相关(r= 0.393,P0.01)。Logistic回归分析显示:高BMI(OR=1.178,P0.05)、心血管并发症(OR=5.035,P0.01)以及低血清ALB(OR=0.852,P0.01)为患者腹膜高转运的危险因素。结论:腹膜透析患者血清ALB水平、BMI和心血管并发症与腹膜高转运相关,可作为预估患者腹膜转运功能的参考指标。
[Abstract]:Objective: to observe the clinical characteristics of continuous ambulatory peritoneal dialysism (CAPDD) patients with different peritoneal transport types, and to explore the related factors affecting peritoneal transport function.Methods: the clinical data of 158 patients with CAPD were retrospectively summarized.According to the peritoneal balance test, the patients were divided into two groups: group A (group A) and group B (group B). The demographic data of the two groups were analyzed.The clinical biochemical indexes and cardiovascular complications were compared, and logistic regression analysis was used to find the related factors affecting the peritoneal transport function of the patients.The rate was significantly higher than that in group B (P 0.05).Conclusion: serum ALB level and cardiovascular complications are associated with high peritoneal transport in peritoneal dialysis patients, which can be used as a reference index for predicting peritoneal transport function in patients with peritoneal dialysis.
【作者单位】：中南大学湘雅三医院肾内科;
【基金】：湖南省卫生厅科研基金(B2012-031) 湖南省卫生和计划生育委员会科研计划项目(C2017007)~~
【分类号】：R459.5

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