常规MR征象在鉴别单发大脑胶质瘤级别中的价值

发布时间：2018-04-12 07:06

本文选题：核磁共振(MR) + 大脑胶质瘤　；参考：《西安交通大学学报(医学版)》2017年06期

【摘要】：目的评估单发大脑胶质瘤常规核磁共振(MR)检查征象在评价大脑胶质瘤高低级别中的价值。方法回顾性分析有手术病理结果的218例单发大脑胶质瘤患者,分为低级别组(134例)和高级别组(84例)。采用t检验、卡方检验和逻辑回归分析评价患者年龄、性别及MR征象(包括接触脑室下区(subventricular zone,SVZ)、不均匀性、肿瘤边界、坏死囊变、出血、跨越中线、占位效应、水肿程度、强化体积、强化不均匀性)在高低级别胶质瘤组间差异及相关性。结果高、低级别胶质瘤组间,年龄有统计学差异(P0.001),性别未见统计学差异(P=0.864)。在MR征象中,接触SVZ(P=0.011)、肿瘤不均匀性(P0.001)、坏死囊变(P=0.037)、水肿程度(P=0.017)、占位效应(P=0.009)、肿瘤边界(P0.001)以及强化体积(P0.001)在两组间有统计学差异。多因素逻辑回归分析显示,年龄、肿瘤坏死囊变、肿瘤边界以及强化程度是高级别胶质瘤的阳性预测值。结论常规MR征象可用于鉴别大脑胶质瘤的高低级别;患者年龄越大、肿瘤坏死囊变越严重、肿瘤边界不清和强化体积越大的,为高级别胶质瘤的可能性越大。
[Abstract]:Objective to evaluate the value of conventional Mr imaging (MRM) in the evaluation of glioma.Methods 218 patients with single brain glioma were analyzed retrospectively. They were divided into low grade group (134 cases) and high grade group (84 cases).T test, chi-square test and logistic regression analysis were used to evaluate the age, sex and Mr signs (including contact with subventricular area subventricular zonetin SVZ, inhomogeneity, tumor boundary, necrotic cysts, bleeding, crossing the midline, occupying effect, edema degree, etc.)Enhancement volume, enhancement heterogeneity) the difference and correlation between high and low grade gliomas.The results showed that there was significant difference in age between high and low grade gliomas (P 0.001), but there was no significant difference in sex (P < 0. 864).In Mr signs, there were significant differences between the two groups in terms of contact with SVZG P0. 011, tumor heterogeneity (P0. 001), necrotic cysts (P0. 037), degree of edema (P0. 017), space occupying effect (P0. 009), tumor boundary (P0. 001) and enhanced volume (P0. 001) between the two groups.Multivariate logistic regression analysis showed that age, necrotic cystic degeneration, tumor boundary and enhancement were positive predictors of high grade gliomas.Conclusion conventional Mr signs can be used to distinguish the high and low grade of brain glioma. The older the patient is, the more serious the necrotic capsule is, the larger the tumor boundary is and the larger the enhancement volume is, the higher the probability of high grade glioma is.
【作者单位】：西安交通大学第一附属医院医学影像科;西安交通大学第一附属医院临床研究中心;
【基金】：国家重点研发计划项目(No.2016YFC0100300) 国家自然科学基金项目(No.81471631,81171317,81201134) 2011年教育部“新世纪优秀人才支持计划”(No.NCET-11-0438) 西安交通大学第一附属医院临床研究课题重点项目(No.XJTU1AF-CRF-2015-004)~~
【分类号】：R445.2;R739.41

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