高温高湿环境下亚低温液体用于失血性休克大鼠的复苏研究

发布时间：2018-04-16 07:58

  本文选题：高温氋湿 + 亚低温　； 参考：《广西医科大学》2017年硕士论文

【摘要】：目的:观察高温高湿环境及创伤失血性休克复合因素作用下,亚低温液体静脉滴注对大鼠核心体温、血清乳酸值、存活率的影响。了解高温高湿环境及失血性休克,这两种复合因素作用下亚低温液体用于复苏的效果和保护作用以提供有效的早期救治手段。方法:采用改良Wigger’s法复制失血性休克模型,依照输注的液体温度随机分为亚低温液体组[液体温度维持在(12±1.5)℃]、常温液体组[液体温度维持在(23±1.5)℃]、假手术组。各组均暴露在气象条件为干球温度(37±0.5)℃,相对湿度(65±5)%的高温高湿环境中,暴露时间为180min,每组12只。记录各组大鼠补液后的存活时间及3小时存活率,比较各组大鼠在补液后30min的血乳酸值,热暴露开始(0时)至热暴露后60min,每隔10min记录大鼠直肠温度的动态变化。结果:(1)亚低温液体组平均存活时间[(155.50±15.89)min]较常温液体组平均存活时间[(83.75±20.56)min]明显延长,差异有统计学意义(P0.05)。(2)亚低温液体组3h存活率为83.3%,常温液体组3h存活率为33.3%。(3)补液30min后亚低温液体组乳酸值(2.86±0.63)较常温液体组(4.48±1.08)低,差异有统计学意义,(P=0.001)。(4)开始补液后,亚低温液体组大鼠直肠温度趋于稳定,常温液体组仍继续上升。结论:高温高湿环境下亚低温液体用于早期失血性休克大鼠的复苏优于常温液体组。
[Abstract]:Aim: to observe the effects of hyperthermia and high humidity environment and traumatic hemorrhagic shock on core body temperature, serum lactate level and survival rate of rats by intravenous infusion of mild hypothermia liquid.To understand the high temperature and high humidity environment and hemorrhagic shock, the effect and protective effect of mild hypothermia liquid on resuscitation under the action of these two kinds of compound factors were studied in order to provide effective early treatment.Methods: the model of hemorrhagic shock was established by modified Wigger's method. According to the infusion temperature, the rats were randomly divided into mild hypothermia liquid group [liquid temperature maintained at 12 卤1.5 鈩僝, normothermic liquid group [liquid temperature maintained at 23 卤1.5 鈩僝, sham operation group.Each group was exposed to high temperature and high humidity (37 卤0.5) 鈩，

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