时间反转聚焦在组织中形成损伤的数值建模

发布时间：2018-04-24 10:35

本文选题：高强度聚焦超声 + 时间反转方法　；参考：《应用声学》2017年02期

【摘要】：为考察基于时间反转方法的高强度聚焦超声治疗在预设目标点处的组织损伤情况,使用三维有限差分算法求解Westervelt方程,建立非线性声波传播数值模型,采用97阵元相控阵结合虚拟源的时间反转方法进行超声聚焦,分析其形成的声场和热场,并考察目标点偏离轴线时的组织损伤形成规律。结果表明随着目标点偏轴距离的增大,声压旁瓣开始增多。旁瓣的温升较低,不足以形成组织损伤。时间反转方法可用于多点聚焦,在一定的范围内,形成多点目标损伤而不产生额外的周围组织损伤。同时多点聚焦可以形成一个较大的损伤区域,减少超声治疗时间。
[Abstract]:In order to investigate the tissue damage at preset target point in high intensity focused ultrasound (HIFU) therapy based on time reversal method, a numerical model of nonlinear acoustic wave propagation was established by solving Westervelt equation with three dimensional finite difference algorithm. The ultrasonic focusing is carried out by using 97 array element phased array combined with the time reversal method of virtual source. The sound field and thermal field are analyzed, and the formation rule of tissue damage when the target point deviates from the axis is investigated. The results show that the sound pressure sidelobes begin to increase with the increase of the distance between the target points and the axis. The temperature rise of the sidelobe is low enough to cause tissue damage. The time reversal method can be used for multi-point focusing. In a certain range, multi-point target damage can be formed without any additional surrounding tissue damage. At the same time, multi-point focusing can form a large area of injury and reduce the time of ultrasound therapy.
【作者单位】：中国科学院声学研究所声场声信息国家重点实验室;中国科学院大学;
【基金】：国家自然科学基金项目(81527901,41274134)
【分类号】：R454.3

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