Lewis血型系统抗体在备血患者中检出情况分析

发布时间：2018-04-28 21:41

本文选题：Lewis血型系统抗体 + 抗-Lea　；参考：《中国输血杂志》2017年01期

【摘要】：目的调查Lewis血型系统抗体在备血患者中的检出率及分布情况。方法对抗体筛选阳性的标本做抗体鉴定。抗体筛选及交叉配血采用微柱凝胶抗球蛋白法及盐水介质试管法;抗体鉴定采用微柱凝胶抗球蛋白法;抗原鉴定采用试管法;并回顾分析本院Lewis血型系统抗体阳性患者的临床资料。结果 94例存在Lewis血型系统抗体患者中,抗-Lea89例,抗-Leb4例,抗-Le~a+Le~b1例,检出率分别是5.69×10~(-4)、0.26×10~(-4)、0.06×10~(-4);Lewis血型均为Le(a-b-);女性患者显著多于男性患者(P0.01);妊娠期患者多见,共35例,占37.2%。17例输血患者,无1例发生溶血反应。结论 Lewis血型系统抗体意义值得探讨,盐水介质试管法和微柱凝胶抗球蛋白2种方法同时配血,可加强输血安全。
[Abstract]:Objective to investigate the detection rate and distribution of Lewis blood group system antibody in patients with blood preparation. Methods the positive samples were identified. Microcolumn gel antiglobulin method and saline medium test tube method were used for antibody screening and cross-matching, microcolumn gel antiglobulin method was used for antibody identification, and test tube method was used for antigen identification. The clinical data of Lewis blood group antibody positive patients were analyzed retrospectively. Results among 94 patients with Lewis blood group system antibodies, 89 were anti-Lea, 4 were anti-Leb, and the positive rates were 5.69 脳 10 ~ (10) ~ (-4) and 0.26 脳 10 ~ (10) ~ (-4) Le~b1, respectively. The results showed that the blood group Lea-b-b was 0.06 脳 10 ~ (10) ~ (-4). The number of female patients was significantly higher than that of male patients (P 0.01). 35 cases (37.22.17 cases) were found in pregnancy. No hemolytic reaction occurred. Conclusion the significance of Lewis blood group system antibody is worth discussing. The combination of two methods, brine medium test tube method and microcolumn gel antiglobulin method, can enhance the safety of blood transfusion.
【作者单位】：中国医科大学附属盛京医院输血科;
【分类号】：R446.6;R457.1

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