臭氧自血疗法对患者凝血功能影响的自身对比研究

发布时间：2018-04-28 22:20

本文选题：臭氧自血疗法 + 血栓弹力图　；参考：《昆明医科大学》2017年硕士论文

【摘要】：[目的]臭氧自血疗法(ozone autohemotherapy treatment, 03-AHT)是一种通过采集患者的静脉血与臭氧混合后再回输到患者体内的治疗方法,在临床上有着广泛的适应症。臭氧自血疗法过程中臭氧本身可以改变血小板的聚集方式,同时也需要加入一定比例的抗凝剂,连续一个疗程十天的治疗是否对凝血功能存在影响,国内外文献鲜有报道。血栓弹力图具有快速准确的测定患者凝血功能的特点。通过对臭氧大自血患者治疗前后进行血栓弹力图测定以了解患者凝血功能变化,从而指导临床治疗。[方法]选择2016年6月至2016年12月在昆明医科大学第一附属医院疼痛科行臭氧自血疗法的患者22例,在经过伦理委员会及患者同意后在第一次行臭氧自血疗法前和最后一次臭氧自血疗法后行血栓弹力图检测患者凝血功能变化,并用A1、A2表示。并对A1、A2两次血栓弹力图R值、K值、Angel角、CI及MA值进行观察分析对比。[结果]1.所有行臭氧自血疗法的22例患者前后两次血栓弹力图检测结果均在正常范围内;2.A1、A2两组的R值、K值、Angel角、CI及MA值进行统计学分析对比发现两组均有统计学意义(P0.05)。[结论] 1.臭氧自血疗法能够使患者凝血功能呈现相对低凝状态;2.臭氧自血疗法对患者凝血功能有影响但在安全范围内,不会引起相关的并发症。
[Abstract]:Objective: ozone autohemotherapy treatment (03-AHT) is a kind of treatment method which is used to collect the venous blood of patients and then infuse it back into the body of the patients. It has a wide range of indications in clinic. Ozone itself can change platelet aggregation in the process of self-blood ozone therapy, and it also needs to add a certain proportion of anticoagulant. It is rarely reported in the literature that whether the treatment of 10 days of continuous treatment has an effect on coagulation function. Thromboelastography has the characteristics of rapid and accurate determination of coagulation function in patients. Thromboelastography was performed before and after treatment to understand the changes of coagulation function in patients with large ozone self-blood, so as to guide the clinical treatment. [methods] from June 2016 to December 2016, 22 patients were treated with ozone self-blood therapy in the Department of pain, first affiliated Hospital of Kunming Medical University. Thromboelastography was performed before the first ozone self-blood therapy and the last ozone self-blood therapy with the consent of the ethics committee and the patient, and the thromboelastogram was used to detect the coagulation function of the patients, as indicated by A1A _ 2. The values of K value, Angel angle CI and MA of A _ 1 A _ 2 thromboelastic map were observed and compared. [result] 1. The results of thromboelastography in all 22 patients who received self-blood ozone therapy were within the normal range. The R value, K value, Angel angle CI and MA value of the two groups were statistically analyzed and compared. The results showed that there was significant difference between the two groups (P 0.05). [conclusion] 1. Ozone self-blood therapy can make the blood coagulation function of patients present a relatively low coagulation state. Ozone self-blood therapy has an effect on coagulation function but does not cause associated complications within a safe range.
【学位授予单位】：昆明医科大学
【学位级别】：硕士
【学位授予年份】：2017
【分类号】：R45

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