慢性阻塞性肺疾病急性加重期患者医院感染病原菌特点与相关因素分析

发布时间：2018-04-28 22:33

本文选题：慢性阻塞性肺疾病 + 急性加重期　；参考：《中华医院感染学杂志》2017年16期

【摘要】：目的探讨慢性阻塞性肺疾病(COPD)急性加重期患者医院感染病原菌特点及相关影响因素。方法选择2015年3月-2016年10月期间医院收治的2 871例COPD急性加重期患者,其中医院感染305例,分析病原菌分布、耐药率及感染因素。结果 305例COPD急性加重期患者痰液中共检出病原菌148株,以革兰阴性菌为主,共93株占62.84%;铜绿假单胞菌最多,其对庆大霉素、头孢他啶、头孢唑林、氨苄西林耐药率较高;多因素logistic回归分析显示,男性、年龄50岁、吸烟、接触粉尘和化学物质及感染为COPD患者发生医院感染的独立危险因素(P0.05)。结论 COPD急性加重期医院感染病原菌主要为革兰阴性菌,且危险因素较多,应针对其危险因素采取积极有效的预防措施,降低其发病。
[Abstract]:Objective to investigate the pathogenic bacteria characteristics of nosocomial infection in patients with acute exacerbation of chronic obstructive pulmonary disease (COPD). Methods A total of 2871 patients with acute exacerbation of COPD were selected from March 2015 to October 2016, including 305 cases of nosocomial infection. The distribution of pathogenic bacteria, drug resistance rate and infection factors were analyzed. Results 148 strains of pathogenic bacteria were detected in sputum of 305 patients with acute exacerbation of COPD, 93 strains were Gram-negative bacteria (62.84%), Pseudomonas aeruginosa was the most resistant to gentamicin, ceftazidime, cefazolin, ampicillin, and the rate of resistance to gentamicin, ceftazidime, cefazolin and ampicillin was higher. Multivariate logistic regression analysis showed that male, age 50 years old, smoking, exposure to dust and chemical substances and infection were the independent risk factors of nosocomial infection in COPD patients (P 0.05). Conclusion the pathogenic bacteria of hospital infection in acute exacerbation of COPD are mainly Gram-negative bacteria, and there are many risk factors. It is necessary to take active and effective preventive measures against the risk factors to reduce the incidence of nosocomial infection.
【作者单位】：温州医科大学附属乐清医院呼吸内科;温州医科大学附属第二医院呼吸内科;
【基金】：浙江省医药卫生基金资助项目(2015KYA214)
【分类号】：R446.5;R563.9

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