2012—2015年医院血流感染病原菌分布及耐药性变迁

发布时间：2018-05-14 00:02

本文选题：血流感染 + 病原菌　；参考：《中国感染控制杂志》2017年10期

【摘要】：目的了解某院2012—2015年血流感染病原菌分布及耐药性变迁特征。方法收集该院2012年1月—2015年12月检验中心微生物室血培养分离病原菌,分为2012—2013年组和2014—2015年组,比较两组菌株的分布特征、构成情况以及对抗菌药物的敏感性。结果两组时间段内分离的病原菌以革兰阴性菌为主,分别占各组菌株的54.96%和54.66%,两组病原菌分布构成比较,差异无统计学意义(P0.05)。革兰阳性球菌对万古霉素和利奈唑胺敏感性高,耐药率均为0;凝固酶阴性葡萄球菌(CNS)对苯唑西林的耐药率均80%,对青霉素的耐药性也均90%;肠杆菌科细菌对亚胺培南、美罗培南的敏感性高,但已出现耐此类药物菌株;两组时间段鲍曼不动杆菌对米诺环素较为敏感,耐药率分别为35.90%和34.55%,对其他药物耐药率均较高(75%)。结论该院血流感染的病原菌耐药菌检出率高,应引起警惕,加强细菌耐药性监测有利于指导临床合理选择和使用抗菌药物。
[Abstract]:Objective to investigate the distribution of pathogenic bacteria and the change of drug resistance of blood stream infection in a hospital from 2012 to 2015. Methods from January 2012 to December 2015, the pathogenic bacteria were collected and separated into 2012-2013 group and 2014-2015 group. The distribution characteristics, composition and antimicrobial susceptibility of the two groups were compared. Results Gram-negative bacteria accounted for 54.96% and 54.66%, respectively, in the two groups. There was no significant difference in the distribution of pathogens between the two groups (P 0.05). Gram-positive cocci were highly sensitive to vancomycin and linazolamine, and resistant rates were 0; coagulase-negative staphylococci (CNS) were resistant to oxacillin 80%, penicillin resistance was 90%; Enterobacteriaceae bacteria were imipenem, and enterobacteriaceae bacteria were resistant to imipenem. Acinetobacter baumannii was sensitive to minocycline in the two groups, the drug resistance rates were 35.90% and 34.55%, respectively. Conclusion the detection rate of drug-resistant bacteria of blood stream infection in this hospital is high, which should arouse vigilance, and strengthen the monitoring of bacterial resistance is helpful to guide clinical rational selection and use of antimicrobial agents.
【作者单位】：兰州大学第一医院;
【基金】：甘肃省科技厅青年科技基金资助项目(1506RJYA261)
【分类号】：R446.5

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