血小板生成素水平在急性炎症状态的变化及其意义探讨

发布时间：2018-05-20 06:13

本文选题：血小板生成素 + 血小板　；参考：《中国实验血液学杂志》2017年03期

【摘要】：目的:探讨血小板生成素(thrombopoietin,TPO)在不同病因引起的急性炎症反应状态下的变化情况,并进一步探讨其意义。方法:采用病例对照分析,纳入65例处于急性炎症反应状态病人作为研究组(其中急性心肌梗死病人15例,急性脑梗死病人15例,急性创伤病人25例,急性肺炎病人10例),42例健康人群作为对照组。使用独立样本t检验方法,对总炎症疾病组与对照组的外周血TPO及各系血细胞计数进行比较,评估急性炎症状态下TPO的水平是否高于健康人群;并使用独立样本Kruskal-Wallis H检验及Nemenyi法检验进一步进行亚组分析,评估在不同病因及不同水平炎症状态下TPO水平是否存在差别。结果:与对照组相比,总炎症疾病组的TPO水平明显升高(181.11±35.38 vs 96.13±9.7 pg/ml,P0.001),且总炎症疾病组白细胞数(9.64±3.43)×10~9/L也明显高于对照组(7.35±1.49)×10~9/L(P0.001)。然而,总炎症疾病组血小板计数与对照组相比并无统计学差异(P=0.313)。在进一步的亚组分析中发现,不同炎症水平状态下TPO水平的变化有不同。高炎症水平状态疾病(急性创伤、急性肺炎)TPO水平较低炎症水平疾病(急性心肌梗死、急性脑梗死)TPO水平明显升高(P0.05),且各组间血小板计数并无明显统计学差异。结论:在急性炎症状态下,TPO血清水平的升高与血小板数无明显相关,但与炎症水平具有相关性,并且TPO可能作为一种急性期反应蛋白对机体产生保护性作用。
[Abstract]:Aim: to investigate the changes of thrombopoietin (TPO) in acute inflammatory reaction induced by different etiology and its significance. Methods: a case-control analysis was carried out in 65 patients with acute inflammatory reaction (including 15 patients with acute myocardial infarction, 15 patients with acute cerebral infarction and 25 patients with acute trauma), including 15 patients with acute myocardial infarction, 15 patients with acute cerebral infarction and 25 patients with acute trauma. Ten patients with acute pneumonia and 42 healthy people were used as control group. The peripheral blood TPO and blood cell count of the total inflammatory disease group and the control group were compared with that of the control group by using independent sample t-test method to evaluate whether the level of TPO in acute inflammatory state was higher than that in healthy population. Kruskal-Wallis H test and Nemenyi test were used to further analyze the subgroup to assess whether there were differences in TPO levels under different etiological factors and different levels of inflammation. Results: compared with the control group, the level of TPO in the total inflammatory disease group was significantly higher than that in the control group (181.11 卤35.38 vs 96.13 卤9.7 PG / ml P 0.001g / L), and the leukocyte count in the total inflammatory disease group was 9.64 卤3.43 脳 10 ~ (-9) / L, which was significantly higher than that in the control group (7.35 卤1.49) 脳 10 ~ (9 / L) P _ (0.001). However, there was no significant difference in platelet count between the total inflammatory disease group and the control group. Further subgroup analysis showed that the changes of TPO levels were different at different inflammatory levels. The level of TPO in patients with high inflammatory state (acute trauma, acute pneumonia) was lower than that in patients with acute myocardial infarction (acute myocardial infarction, acute cerebral infarction), the level of TPO was significantly increased (P 0.05), and there was no significant difference in platelet count among the groups. Conclusion: there is no significant correlation between the serum level of TPO and platelet count in acute inflammatory state, but there is a correlation with the level of inflammation, and TPO may play a protective role as a reactive protein in acute phase.
【作者单位】：南方医科大学南方医院血液科;南方医科大学南方医院儿科;佛山市第一人民医院急诊科;江西省肿瘤医院内一科;
【分类号】：R446.1

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