轻中度血管狭窄重构模式与斑块易损性的高分辨磁共振研究

发布时间：2018-05-22 14:56

本文选题：动脉粥样硬化 + 血管重构　；参考：《第三军医大学学报》2017年18期

【摘要】：目的应用高分辨磁共振成像技术评估轻中度狭窄的颈动脉血管重构模式,探讨血管重构模式与颈动脉斑块在缺血性脑卒中事件发生、发展中的关系。方法纳入经超声诊断颈动脉粥样硬化,且斑块≥2 mm发生急性缺血性脑梗死或短暂性脑缺血的患者32例,进行高分辨磁共振斑块成像。根据斑块的信号、表面纤维帽的完整性判定斑块的稳定情况;同时测量斑块最厚层面、远端及近端参考点的总管腔、管壁面积,计算出管壁标准化指数、重构指数(remodeling index,RI)、斑块负荷及斑块大小。RI≥1.05为正性重构(positive remodeling,PR),RI1.05为非正性重构(non-positive remodeling,nonPR)。比较PR组与Non-PR组测量指标的差异,并对重构模式与斑块易损性进行相关性分析。结果共检出55个颈动脉斑块,PR组与Non-PR组在总管腔、管壁面积、管壁标准化指数上差异无统计学意义(P0.05),两组斑块负荷及斑块大小差异有统计学意义(P0.001)。重构模式与斑块易损性的相关性分析差异无统计学意义(χ~2=0.532,P0.05)。结论轻中度血管狭窄早期以PR为主,重构模式与斑块的易损性无正性相关,斑块自身成分的变化是导致缺血性脑卒中事件发生至关重要因素。
[Abstract]:Objective To evaluate the relationship between vascular remodeling pattern and carotid plaque in the development of ischemic stroke . Results There were no significant differences between the reconstructed model and the non - PR group ( P0.05 ) . There was no significant difference between the two groups ( P < 0.05 ) . There was no significant difference between the two groups ( P < 0.01 ) . Conclusion The early stage of mild - to - moderate vessel stenosis is mainly PR , and the remodeling pattern is related to the vulnerability of the plaque , and the change of the component of plaque itself is a key factor leading to the occurrence of ischemic stroke .
【作者单位】：第三军医大学西南医院放射科;
【分类号】：R445.2;R743.3

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