小儿大肠埃希菌血流感染的临床特点与药物敏感分析

发布时间：2018-05-27 22:09

本文选题：大肠埃希菌 + 血流感染　；参考：《中国消毒学杂志》2017年07期

【摘要】：目的分析儿童大肠埃希菌血流感染的临床特点及其对常用抗菌药物的药敏试验结果,为防控相关感染提供依据。方法回顾性收集某医院2013年1月-2015年10月确诊为大肠埃希菌感染的82例患儿临床资料,分析阳性菌株的血清分型与药物敏感性试验结果。结果发生大肠埃希菌血流感染的患儿以年龄在30 d内最多,占54.9%;有53.6%的患儿来自新生儿科,20.7%患儿患有血液肿瘤病;临床分离的大肠埃希菌的血清型以O142K86、O126K71、O44K74、O127K63、O55K59居前5位,其中以O142K86型最为多见,占24.4%。药敏试验显示,临床分离株对氨苄西林和头孢唑林的耐药率最高,分别为76.8%和70.7%;头孢亚胺培南和和哌拉西林他唑巴坦最为敏感,敏感染率均达到了97.6%。结论该医院大肠埃希菌血流感染发病以新生儿及存在血液病等基础病患儿发病率高,易侵犯中枢神经系统而诱发化脓性脑膜炎。
[Abstract]:Objective to analyze the clinical characteristics of blood stream infection of Escherichia coli in children and the results of antimicrobial susceptibility test in order to provide evidence for prevention and control of related infections. Methods the clinical data of 82 children diagnosed with Escherichia coli infection from January 2013 to October 2015 were retrospectively collected and the results of serotyping and drug sensitivity tests were analyzed. Results the most children with blood flow infection of Escherichia coli were within 30 days (54.9%), 53.6% of the children were from neonatal pediatrics (20.7%) had blood tumor disease, and the serotype of clinical isolated Escherichia coli was O142K86O126K71O44K7O127K63O55K59 in the first five places, and the most common serotype of Escherichia coli was O142K86O126K71O44K7O127K63O55K59. O142K86 type was the most common, accounting for 24. 4%. The drug sensitivity test showed that the drug resistance rates of clinical isolates to ampicillin and cefazolin were 76.8% and 70.7 respectively, and cefimipenem and piperacillin tazobactam were the most sensitive, and the sensitive infection rate was 97.6g. Conclusion the incidence of blood stream infection of Escherichia coli in this hospital is high in newborns and children with basic diseases such as hematologic diseases and it is easy to invade the central nervous system and induce suppurative meningitis.
【作者单位】：南京医科大学附属儿童医院;
【基金】：江苏省人社厅“六大人才高峰”资助项目(2016-WSN-193) 南京市科委项目(201605048)
【分类号】：R446.5;R725.1

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