严重脓毒症患者中性粒细胞明胶蛋白酶相关脂质运载蛋白与死亡和MODS的相关性

发布时间：2018-06-02 01:51

本文选题：中性粒细胞明胶蛋白酶相关脂质运载蛋白 + 脓毒症　；参考：《江苏医药》2017年06期

【摘要】：目的探讨血浆中性粒细胞明胶蛋白酶相关脂质运载蛋白(NGAL)水平对严重脓毒症患者死亡和多器官功能障碍综合征(MODS)的预测价值。方法分析123例严重脓毒症和脓毒性休克患者血浆NGAL水平与发生MODS和死亡的相关性。结果 7d内47例发生MODS[第1天10例(8%),第7天37例(30%)]。12个月内发生死亡39例(32%)。高血浆NGAL水平组较低水平组出现MODS和死亡的风险更高(P0.05)。ROC曲线分析显示,血浆NGAL水平对ICU内死亡病例有预测价值。Cox回归分析在校正混杂的危险因素后显示,血浆NGAL水平升高是死亡(HR=2.128,95%CI=1.078~4.203,P0.05)和MODS(HR=1.896,95%CI=1.012~3.552,P0.05)的独立预测因素。结论血浆NGAL水平升高是严重脓毒症患者MODS和死亡的独立预测因素。
[Abstract]:Objective to investigate the predictive value of plasma neutrophil gelatinase-associated lipid carrier protein (NGALs) levels in patients with severe sepsis and multiple organ dysfunction syndrome (MODSs). Methods Plasma NGAL levels were analyzed in 123 patients with severe sepsis and septic shock. Results MODS was found in 47 cases within 7 days [10 cases had MODS on the first day, 37 cases on the 7th day] and 39 cases died within 12 months. There was a higher risk of MODS and death in the higher plasma NGAL level group than in the lower group. The results of P0.05? ROC curve analysis showed that the plasma NGAL level had predictive value to the death cases in ICU. The regression analysis showed that after adjusting for the mixed risk factors, the plasma NGAL level was significantly higher than that in the lower group. The increase of plasma NGAL level was an independent predictor of HR1. 128 ~ 95 CI 1.078 and 4. 203 P0.05) and MODS HR1. 896 ~ 95% CI 1.012 ~ 3. 552 P 0. 05). Conclusion elevated plasma NGAL level is an independent predictor of MODS and death in patients with severe sepsis.
【作者单位】：苏州市立医院(南京医科大学附属苏州医院)重症医学科;上海市奉贤区奉城医院(上海交大九院奉城分院)ICU;
【基金】：苏州市科教兴卫青年项目(KJXW2013028)
【分类号】：R459.7

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