西安地区住院患者与健康人群Rh血型分布特征

发布时间：2018-06-07 02:43

本文选题：Rh抗原 + Rh抗体　；参考：《中国输血杂志》2017年04期

【摘要】：目的了解西安地区住院患者与健康人群Rh血型分布特征,探讨Rh抗原分型检测在临床输血安全中的意义。方法采用血清学方法对10 898例住院患者和5 121例健康人做Rh抗原分型检测,并对住院患者进行不规则抗体筛查和鉴定。结果住院患者与健康人群的RhD阳性表型分布频率差异有统计学意义,并且在构成比中,住院患者表型Dccee(0.42%)DCc EE(0.12%),而健康人DCc EE(0.33%)Dccee(0.21%);在RhD阳性患者中,Rh表型以CCee和Cc Ee为优势表型,在RhD阴性患者中,Rh表型以ccee和Ccee为优势表型;Rh 5种抗原的阴性率由高到低依次为E(51.24%)c(41.42%)C(12.04)e(7.82%)D(0.83%);在检出的37例同种抗体中,Rh抗体28例,占75.7%,其中抗-E17例,抗-c E4例,抗-D3例,抗-Ce2例,抗-C1例,抗-c1例。结论应用Rh抗原分型检测技术,选择与患者Rh表型相匹配的献血员红细胞输注,可在一定程度上减少同种抗体的产生,降低输血不良反应的发生率。
[Abstract]:Objective to investigate the distribution characteristics of Rh blood group in inpatients and healthy people in Xi'an, and to explore the significance of Rh antigen typing in clinical transfusion safety. Methods Rh antigen typing was performed in 10 898 hospitalized patients and 5 121 healthy persons by serological method, and irregular antibodies were screened and identified. Results the frequency of RhD positive phenotypic distribution was significantly different between the inpatients and the healthy people. In the composition ratio, the phenotypic phenotypes of Dccee(0.42%)DCc were 0.12 in the inpatients, 0.33 in the healthy subjects, 0.21 in the healthy subjects, and the predominant phenotypes of the Rh phenotypes in the RhD positive patients were CCee and Cc-Ee. In RhD negative patients, the negative rate of Rh 5 antigens with ccee and Ccee as the dominant phenotypes was 51.242.The negative rate of Rh was 41.42 and 41.42%, and 28 of the 37 homoantibodies were detected, accounting for 75.7E4, including anti-E17, anti-C, anti--D3, anti-Ce2, and anti-CE2, respectively, in 37 patients with RhD negative phenotypes, the positive rate of Rh antibodies was 75.7%, including anti-E 17 cases, anti-C cases, anti--D3 cases, anti-E 2 cases, anti-De 3 cases, anti-ce 2 cases, and the negative rates of Rh antigens were 75.7E4%, 75.7E4%, 75.7E4% and 75.7E4% respectively. Anti-C1 and anti-c were found in 1 case. Conclusion Rh antigen typing technique and Rh matching Rh phenotype matching red blood cell transfusion can reduce the generation of homologous antibody and decrease the incidence of adverse reaction of blood transfusion to a certain extent.
【作者单位】：西安交通大学医学部基础医学院病原生物学与免疫学系;西安交通大学第一附属医院输血科;陕西省血液中心;
【分类号】：R457.11

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