肝肾综合征大鼠模型的建立及彩色多普勒超声肾血流参数的特点

发布时间：2018-06-07 09:31

本文选题：肝肾综合征 + 大鼠模型　；参考：《中国超声医学杂志》2017年08期

【摘要】：目的应用彩色多普勒超声观察肝肾综合征大鼠模型肾血流参数的特点。方法建立肝肾综合征大鼠模型,行生化、病理、尿量等检测,彩色多普勒超声影像对肾动脉血流参数进行评估。结果模型组与正常、生理盐水(NS)组相比:血中ALT、AST、BUN、CR均明显升高(P0.05),ALB、24h尿量明显减少(P0.05),正常组与NS组间差异无统计学意义(P0.05)。病理结果提示模型组肝脏形成了大量假小叶,肾组织未见异常。以上表明模型构建成功。超声影像提示各组大鼠肾脏大小及内部回声无明显差异,模型组与正常、NS组比较肾动脉RI明显增高(P0.05),PSV、EDV明显降低(P0.05),正常组与NS组间差异无统计学意义(P0.05)。结论超声影像可对肝肾综合征大鼠模型肾血流动力学改变进行诊断和评估。
[Abstract]:Objective to observe the characteristics of renal blood flow parameters in rats with hepatorenal syndrome by color Doppler ultrasound. Methods the rat model of hepatorenal syndrome was established and the parameters of renal artery blood flow were evaluated by color Doppler ultrasound. Results compared with the normal group and NS group, the blood alt of the model group was significantly higher than that of the NS group. The 24-hour urine volume of ALB was significantly decreased in the model group. There was no significant difference between the normal group and the NS group (P 0.05). The pathological results showed that a large number of pseudolobules were formed in the liver of the model group, and no abnormal renal tissue was found in the model group. The above results show that the model has been successfully constructed. Ultrasound images showed that there was no significant difference in renal size and internal echo between the two groups. The RI of renal artery in the model group was significantly higher than that in the normal NS group. The EDV of PSV in the model group was significantly lower than that in the normal group, but there was no significant difference between the normal group and the NS group. Conclusion Ultrasound can be used to diagnose and evaluate renal hemodynamic changes in rats with hepatorenal syndrome.
【作者单位】：南昌大学医学院;江西省妇幼保健院超声科;赣南医学院第一附属医院超声科;江西省儿童医院普外科;
【基金】：江西省教育厅科技计划(No.GJJ14769) 南昌大学研究生创新基金资助项目(No.cx2016309)
【分类号】：R-332;R445.1;R575.2;R692

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