乙型肝炎患者病毒复制指标与乙肝标志物及肝功能关系分析

发布时间：2018-06-07 20:56

  本文选题：乙型肝炎 + HBV　； 参考：《临床和实验医学杂志》2017年03期

【摘要】：目的探讨乙型肝炎患者病毒复制指标(HBV DNA)与乙肝标志物及肝功能的关系。方法对68例乙型肝炎患者采用电化学发光法检测血清中的乙型肝炎e抗体(HBe Ab)、核心抗体(HBc Ab)、e抗原(HBe Ag)、表面抗体(HBs Ab)、表面抗原(HBs Ag)水平。采用实时荧光定量法检测血清中的HBV DNA水平,采用全自动生化仪检测血清中的天门冬氨酸氨基转移酶(AST)、丙氨酸氨基转移酶(ALT)和胆碱酯酶(CHE)。结果 HBs Ag/HBe Ag/HBc Ab阳性组(大三阳组)患者血清中的HBV DNA阳性率以及定量结果高于其他组(P0.05);HBe Ag阳性组中HBVDNA的阳性表达率高于HBe Ag阴性组中HBV DNA的阳性表达率(P0.05);HBV DNA载量≤10~3、10~3HBV DNA载量106、HBV DNA载量≥106的患者间血清AST和ALT水平差异有统计学意义(P0.05),随着HBVDNA载量的增加血清AST和ALT显著增加;但三组间的CHE差异无统计学意义(P0.05)。结论乙型肝炎患者HBV DNA水平和乙肝患者的病毒复制情况、炎症程度有着密切的联系,但需要与乙肝标志物结合才能更加客观和准确的评价患者的病情变化和严重程度。
[Abstract]:Objective to investigate the relationship between HBV DNA and HBV markers and liver function in patients with hepatitis B. Methods 68 patients with hepatitis B were detected by electrochemiluminescence assay (ECL) to detect the levels of HBe Aban, HBe Agn, HBs Abn, HBeAg and HBeAg in the serum of 68 patients with hepatitis B. The levels of HBV DNA in serum were detected by real-time fluorescence quantitative method. Aspartate aminotransferase (ASTT), alanine aminotransferase (alt) and cholinesterase (CHEE) in serum were detected by automatic biochemical instrument. Results the positive rate and quantitative results of HBV DNA in serum of patients with HBs Ag / HBe / HBc Ab positive group were higher than those in other groups (P 0.05 + HBe Ag positive group) than those in HBe Ag negative group (P 0.05) and the positive rate of HBV DNA loaded with HBV DNA was higher than that in HBe Ag negative group. There was significant difference in serum AST and alt levels between patients with HBV DNA load 鈮，

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