脑梗死运动脑区结构和功能变化的MRI研究

发布时间：2018-06-15 02:53

本文选题：脑梗死 + 灰质体积　；参考：《中国医药导报》2017年07期

【摘要】：目的探讨慢性期脑桥脑梗死患者运动相关脑区结构和功能变化。方法选择2006年1月~2010年6月于天津医科大学总医院神经内科就诊的16例慢性期脑桥脑梗死患者,选择25例健康志愿者为对照组。采用3.0T磁共振扫描仪行全脑高分辨率解剖像及静息态fMRI扫描。采用SPM8软件对脑桥脑梗死组与对照组灰质体积行组间比较。将灰质体积存在差异的脑区定义为ROIs,进行基于ROIs的全脑水平rsFC分析。采用SPM8软件对脑桥脑梗死组与对照组功能连接模式进行组间比较。结果与对照组相比,脑桥脑梗死组患者灰质体积缩小区为健侧小脑半球后叶及蚓部(校正后P0.05,T峰值=-4.438);灰质体积增加区为健侧M1区(校正后P0.05,T峰值=4.4126)及双侧SMA(校正后P0.05,T峰值=4.7229)。与对照组相比,脑桥脑梗死组患者健侧小脑半球与健侧PMC(校正后P0.05,T峰值=4.1639)及双侧SMA(校正后P0.05,T峰值=4.4663,4.1639)连接增强;健侧M1区与同侧PMC连接增强(校正后P0.05,T峰值=3.8291),与同侧小脑半球连接减弱(校正后P0.05,T峰值=-5.0192);双侧SMA与健侧中央后回(校正后P0.05,T峰值=3.9016)及双侧小脑半球(校正后P0.05,T峰值=4.1569,4.2991)连接增强。结论脑桥脑梗死可造成远隔运动相关脑区结构改变;脑桥脑梗死既存在结构代偿也存在功能代偿。
[Abstract]:Objective to investigate the structural and functional changes of motor related brain in patients with chronic pontine infarction. Methods from January 2006 to June 2010, 16 patients with chronic pontine infarction were selected from Department of Neurology, General Hospital of Tianjin Medical University, and 25 healthy volunteers were selected as control group. The 3. 0 T magnetic resonance scanner was used to scan the whole brain with high resolution anatomy and rest fMRI. The volume of gray matter in pontine infarction group and control group were compared by SPM 8 software. The brain area with different gray matter volume is defined as ROIs. the whole brain level RsFC analysis based on ROIs is carried out. SPM 8 software was used to compare the functional connection mode between the pons infarction group and the control group. Results compared with the control group, the reduced gray matter volume in the pontine infarction group was located in the contralateral posterior lobe and vermis of the cerebellar hemisphere (corrected P0.05T peak value was -4.438), the gray matter volume increased area was the normal M1 area (corrected P0.05T peak value was 4.4126) and bilateral SMAs (the corrected P0.05T peak value was 4.7229m). Compared with the control group, the connections between the contralateral cerebellar hemisphere and the contralateral PMC (the peak value of P0.05T after correction were 4.1639) and the bilateral SMAs (the peak value of P0.05T after correction were 4.4663c4.1639) were enhanced in the patients with pontine infarction. The connection between M1 region and PMC was enhanced (the peak value of P0.05T was 3.8291U after correction, the connection with the ipsilateral cerebellar hemisphere was weakened (P0.05T peak after correction) -5.0 1922, bilateral SMA was enhanced with the postcentral gyrus of contralateral (P0.05T peak after correction 3.9016) and bilateral cerebellar hemispheres (P0.05T peak was 4.15694.2991 after correction). Conclusion Pons infarction can cause structural changes in distant motor related brain areas, and there is both structural compensation and functional compensation in pons infarction.
【作者单位】：天津市医科大学总医院放射科;
【基金】：国家自然科学基金面上项目(81271564) 国家卫生计生委公益性行业科研专项项目(201402019) 天津市自然科学基金重点项目(12JCZDJC23800)
【分类号】：R445.2;R743.33

【相似文献】