克氯米芬治疗不孕症对子宫内膜容受性影响的三维超声评价

发布时间：2018-06-16 13:06

本文选题：超声检查 + 三维　；参考：《临床超声医学杂志》2017年01期

【摘要】：目的应用三维超声评价克氯米芬治疗不孕症对子宫内膜容受性的影响,探讨其对妊娠结局的影响。方法选取接受克氯米芬促排卵治疗的不孕患者46例,按妊娠结局分为妊娠组(17例)与非妊娠组(29例),分别于用药前后应用经阴道三维超声测量子宫内膜容积、厚度、子宫内膜及内膜下的血流分布类型、血管指数(VI)、血流指数(FI)、血管血流指数(VFI)、搏动指数(PI)、收缩峰速度与舒张末期速度比值(S/D)、阻力指数(RI)、收缩期峰值(PS)及舒张末期血流速度(ED),结果进行对比分析。结果两组患者用药前后子宫内膜厚度和容积比较差异均无统计学意义。用药前两组子宫内膜及内膜下血流相关参数比较差异均无统计学意义,用药后妊娠组RI、PI、ED、VI及VFI均降低,S/D、PS及FI升高,差异均有统计学意义(均P0.05)。46例患者用药后子宫内膜及内膜下血流分布类型与用药前比较差异有统计学意义(P0.05),A型血流内膜患者增多。结论克氯米芬促排卵治疗后对不孕症患者子宫内膜厚度和容积影响不大,克氯米芬治疗后子宫内膜及内膜下血流灌注状况改善的患者更有利于妊娠,三维超声检测血流参数可用于评价子宫内膜容受性并预测妊娠结局。
[Abstract]:Objective to evaluate the effect of clomiphene on endometrial receptivity and pregnancy outcome by three-dimensional ultrasound. Methods 46 infertile patients who received clomiphene ovulatory therapy were divided into pregnancy group (n = 17) and non-pregnancy group (n = 29) according to pregnancy outcome. The volume and thickness of endometrium were measured by transvaginal three-dimensional ultrasound before and after treatment. Blood flow patterns of endometrium and subendometrium, The results were compared and analyzed. The ratio of systolic peak velocity to end-diastolic velocity was S / D ~ (1), resistance index (RI), systolic peak value (PSN) and end diastolic velocity (EDV). Results there was no significant difference in endometrial thickness and volume between the two groups. There was no significant difference in the parameters of endometrial and subendometrial blood flow between the two groups before and after treatment. There was significant difference in the distribution of endometrial and subendometrial blood flow in 46 patients after treatment. Conclusion the thickness and volume of endometrium in infertile women were not significantly affected after ovulation induction treatment with clomiphene. The patients with improved endometrial and subendometrial blood perfusion after clomiphene treatment were more beneficial to pregnancy. Three-dimensional ultrasound can be used to evaluate endometrial receptivity and predict pregnancy outcome.
【作者单位】：三峡大学医学院;三峡大学第二临床医学院超声科;
【基金】：湖北省宜昌市科技研究与开发项目(A12301-48)
【分类号】：R445.1;R711.6

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