安徽滁州市第一人民医院2015年临床分离菌的耐药性监测

发布时间：2018-06-20 14:15

本文选题：细菌耐药性 + 超广谱β内酰胺酶　；参考：《中国感染与化疗杂志》2017年02期

【摘要】：目的了解2015年安徽滁州市第一人民医院常见分离菌的临床分布及耐药情况。方法各类临床分离菌采用Micro Scan Walk Away 96 PLUS进行鉴定和药敏试验,采用WHONET5.6软件对数据进行统计分析。结果 2015年共分离病原菌1 499株,其中革兰阳性菌370株,占24.7%;革兰阴性菌1 129株,占75.3%。葡萄球菌中耐甲氧西林金黄色葡萄球菌(MRSA)和凝固酶阴性葡萄球菌(MRCNS)的检出率分别为37.0%和86.3%。葡萄球菌中未见万古霉素、达托霉素和利奈唑胺耐药株。肠球菌中粪肠球菌对达托霉素、万古霉素和利奈唑胺均敏感,屎肠球菌中检出1株耐万古霉素,检出率为2.8%。肺炎链球菌主要来源于儿科,对青霉素均敏感。大肠埃希菌、克雷伯菌属(肺炎克雷伯菌和产酸克雷伯菌)和奇异变形杆菌产ESBL的检出率分别为52.9%、30.8%和25.0%,产ESBL株对测试药物的耐药率均高于非产ESBL株。铜绿假单胞菌对亚胺培南和美罗培南的耐药率均为29.4%。不动杆菌属(鲍曼不动杆菌占85.5%)对亚胺培南和美罗培南的耐药率分别为63.0%和64.5%。结论 2015年该院分离的革兰阴性杆菌耐药严重,尤其是碳青霉烯类耐药的肠杆菌科细菌检出率较高,应引起重视。
[Abstract]:Objective to investigate the clinical distribution and drug resistance of common isolated bacteria in the first people's Hospital of Chuzhou City Anhui Province in 2015. Methods MicroScan Walk Away 96 plus and WHONET5.6 software were used to identify and analyze the clinical isolates. Results A total of 1 499 strains of pathogenic bacteria were isolated in 2015, of which 370 were Gram-positive bacteria (24.775%) and 1,129 Gram-negative bacteria (75.33B). The positive rates of methicillin-resistant Staphylococcus aureus and coagulase-negative staphylococcus were 37.0% and 86.3%, respectively. Vancomycin, daptomycin and linazolamide resistant strains were not found in Staphylococcus. Enterococcus faecalis was sensitive to daptomycin, vancomycin and linazolamide. One strain of Enterococcus faecium was found to be resistant to vancomycin, and the detection rate was 2.8%. Streptococcus pneumoniae mainly comes from paediatrics and is sensitive to penicillin. The ESBL production rates of Escherichia coli, Klebsiella pneumoniae and Proteus mirabilis were 52.9% and 25.0%, respectively. The drug resistance rate of ESBL producing strains was higher than that of non-ESBL producing strains. The resistance rates of Pseudomonas aeruginosa to imipenem and meropenem were 29.4%. The resistance rates of Acinetobacter (Acinetobacter baumannii) to imipenem and meropenem were 63.0% and 64.5%, respectively. Conclusion Gram-negative bacilli isolated in our hospital in 2015 were highly resistant, especially carbapenem resistant Enterobacteriaceae, which should be paid more attention to.
【作者单位】：安徽省滁州市第一人民医院检验科;
【分类号】：R446.5

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