鲍曼不动杆菌对消毒剂耐药机制的研究

发布时间：2018-07-11 13:03

本文选题：鲍曼不动杆菌 + 消毒剂　；参考：《中国抗生素杂志》2017年02期

【摘要】：鲍曼不动杆菌是主要的医院获得性病原菌之一。临床分离的鲍曼不动杆菌不仅对抗菌药物具有耐药性,而且对控制感染的消毒剂或杀菌剂具有耐药性。耐药表型的特点对于抗菌药物的治疗和感染控制是一个巨大的挑战。虽然消毒剂与抗菌药物相比往往具有不同作用方式和较高的使用浓度,但是鲍曼不动杆菌已经发展了多种机制来抵抗消毒剂的作用。因此,鲍曼不动杆菌对消毒剂的耐药一旦获得,对感染的控制是一个不利的影响。此外,已经观察到鲍曼不动杆菌对消毒剂和抗菌药物耐药性之间的联系,这是由于诸如外排泵或抗菌药物和消毒剂耐药基因共存而造成。由消毒剂和抗生素抗性的共同选择作用还有待进一步研究,但需要一个策略来优化消毒剂的使用效能和减少消毒剂耐药性的发展。本文主要就鲍曼不动杆菌消毒剂的耐药机制进行综述。
[Abstract]:Acinetobacter baumannii is one of the major nosocomial pathogens. Acinetobacter baumannii isolated clinically is not only resistant to antimicrobial agents but also to disinfectants or fungicides that control infection. The phenotypic characteristics of drug resistance are a great challenge for the treatment and infection control of antimicrobial agents. Although disinfectants tend to have different ways of action and higher concentration than antimicrobial agents, Acinetobacter baumannii has developed a variety of mechanisms to resist the effects of disinfectants. Therefore, Acinetobacter baumannii resistance to disinfectants, once obtained, the control of infection is a negative impact. In addition, a link has been observed between the resistance of Acinetobacter baumannii to disinfectants and antimicrobial agents due to the coexistence of genes such as efflux pumps or antimicrobial agents and disinfectant resistance. The common selection of disinfectants and antibiotic resistance remains to be further studied, but a strategy is needed to optimize the efficacy of disinfectants and reduce the development of drug resistance of disinfectants. This article reviews the mechanism of drug resistance of Acinetobacter baumannii disinfectants.
【作者单位】：成都医学院结构特异性小分子药物研究四川省高校重点实验室;成都医学院药物研究所;成都医学院科研中心;
【基金】：国家自然科学基金委项目(No.81373454) 四川省科技厅重点科技项目(No.2013jy0065)
【分类号】：R446.5

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