糖尿病肾病患者ACR与血清氧化应激、血管新生指标以及外周血T细胞含量的关系

发布时间：2018-07-14 13:29

【摘要】：目的:研究糖尿病肾病患者微量白蛋白/尿肌酐比值(ACR)与血清氧化应激、血管新生指标以及外周血T细胞含量的相关性。方法:选择2型糖尿病患者进行回顾性分析,筛选ACR3mg/mmol、3~30mg/mmol、30mg/mmol的患者分别作为研究的DM1组、DM2组、DM3组;另取健康志愿者作为对照组。采集血清并测定氧化应激指标、血管新生指标,采集外周血并测定T细胞含量。结果:DM1组、DM2组、DM3组患者血清中SOD、GSH-Px、CAT的含量以及外周血中Th2、Treg的含量均显著低于对照组且ACR越高,血清中SOD、GSH-Px、CAT的含量以及外周血中Th2、Treg的含量均越低;DM1组、DM2组、DM3组患者血清中MDA、8-OHdG、VEGF、Ang1、Ang2的含量以及外周血中Th1、Th17的含量均显著高于对照组且ACR越高,血清中MDA、8-OHdG、VEGF、Ang1、Ang2的含量以及外周血中Th1、Th17的含量均越高。结论:氧化应激反应增强、血管新生增多以及T淋巴细胞紊乱与糖尿病肾病的病情发展密切相关。
[Abstract]:Aim: to study the relationship between serum oxidative stress, angiogenesis index and T cell content in peripheral blood of diabetic nephropathy patients with microalbuminuria / urinary creatinine ratio (ACR). Methods: the patients with type 2 diabetes mellitus were selected for retrospective analysis. The patients with ACR 3mg / mmoltrol or 30mg / mmol ACR were selected as the DM1 group and the healthy volunteers as the control group. Serum was collected, oxidative stress index and angiogenesis index were measured, peripheral blood was collected and T cell content was measured. Results the content of GSH-PxCT-cat in serum and Th2treg in peripheral blood were significantly lower in the control group than in the control group, and the higher the ACR was, the higher the ACR was. The lower the content of GSH-PxCT-cat in serum and Th2treg in peripheral blood of DM1 group, the higher the level of MDA-8-OHdGG VEGFAng1VEGFAng1 Ang2 in serum and Th1Th 17 in peripheral blood, and the higher the ACR level was, the higher the level of Th _ 2T _ (17) in serum was, and the higher the level of Th2T _ (17) in peripheral blood was, the higher the level of Th _ (2) Th _ (17) was in serum. The higher the level of MDA-8-OHdGN VEGF Ang1 Ang2 in serum and Th1 Th 17 in peripheral blood. Conclusion: the increase of oxidative stress, angiogenesis and T lymphocyte disorder are closely related to the development of diabetic nephropathy.
【作者单位】：上海市静安区石门二路街道社区卫生服务中心检验科;上海德达医院检验科;
【分类号】：R587.2

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