Extended Tofts与Exchange模型的动态对比增强MRI参数在鉴别细胞型子宫肌瘤中应用
发布时间：2018-07-14 15:11
【摘要】：目的探讨Extended Tofts和Exchange两种模型的动态对比增强MRI(DCE-MRI)参数在鉴别细胞型子宫肌瘤中的应用价值。方法搜集2015年10月至2016年6月经手术病理证实的32例子宫肌瘤患者,术前行盆腔多期DCE-MRI,选择Extended Tofts和Exchange血流动力学模型分别计算子宫肌瘤的定量灌注参数K~(trans)、PS、Fp、K_(ep)、V_e、V_p。术后按病理分型分为细胞型、普通型、退变型3组,对比分析3组子宫肌瘤灌注参数的组间差异;筛选出有统计学意义的参数,绘制鉴别细胞型子宫肌瘤的ROC曲线;使用Pearson相关性分析观察两种模型间的参数有无相关性。结果在3组子宫肌瘤间,Extended Tofts模型中的K~(trans)、Kep、Vp及Exchange模型中的Fp、K_(ep)、V_p值差异有统计学意义(P0.05),且这些参数在鉴别细胞型子宫肌瘤的ROC曲线下面积分别为1.000、0.923、0.827、1.000、0.702、0.738;Extended Toft模型中的K~(trans)与Exchange模型中的PS和Fp相关(r=0.365,P=0.034,r=0.968,P=0.000),K_(ep)、V_p在两种模型中呈正相关(r=0.454,P=0.007,r=0.479,P=0.004),两种模型间的Ve值无相关性。结论 Extended Tofts模型中的K~(trans)、K_(ep)、V_p及Exchange模型中的Fp、K_(ep)、V_p值在鉴别细胞型子宫肌瘤中的应用价值较高,特别是Extended Tofts模型中的K~(trans)值和Exchange模型中的Fp值诊断效能最高,且两者具有明显的相关性;同时Extended Tofts模型的K_(ep)、V_p值诊断效能优于Exchange模型。
[Abstract]:Objective to explore the application value of dynamic contrast enhanced MRI (DCE-MRI) parameters of two models of Extended Tofts and Exchange in the identification of cell myoma of the uterus. Methods 32 cases of uterine myoma confirmed by surgical pathology from October 2015 to 2016 were collected and the pelvic multistage DCE-MRI was performed before operation, and Extended Tofts and Exchange hemodynamics were selected. The quantitative perfusion parameters K~ (trans), PS, Fp, K_ (EP), V_e, V_p. were separately calculated and divided into 3 groups of cells, common type and degeneration type, and compared and analyzed the differences between the 3 groups of uterine myoma perfusion parameters. The statistical parameters were selected to draw the ROC curve of the differentiation of the myoma of the uterus; the Pearson phase was used. There was no correlation between the parameters between the two models. Results in the 3 groups of uterine myomas, the K~ (trans), Kep, Vp and Exchange models were Fp, K_ (EP), V_p values in the Extended Tofts model. The K~ (trans) in the Extended Toft model is related to the PS and Fp in the Exchange model (r=0.365, P=0.034, r=0.968, P=0.000), and there is a positive correlation between the two models. The value of Fp, K_ (EP) and V_p is of high value in the identification of cell myoma of the uterus, especially the K~ (trans) value in the Extended Tofts model and the Fp value in the Exchange model is the highest, and the two have obvious correlation. Meanwhile, the Extended Tofts model is better than the model.
【作者单位】： 浙江大学绍兴医院(绍兴市人民医院)放射科;绍兴市中心医院放射科;浙江大学医学院附属邵逸夫医院放射科;
【基金】：浙江省科技厅公益技术研究社会发展项目(编号:2014C33151) 浙江省医药卫生一般研究计划项目(编号:2014KYA215) 绍兴市公益性应用计划项目(编号:2013D10039)
【分类号】：R445.2;R737.33
本文编号：2122047
[Abstract]:Objective to explore the application value of dynamic contrast enhanced MRI (DCE-MRI) parameters of two models of Extended Tofts and Exchange in the identification of cell myoma of the uterus. Methods 32 cases of uterine myoma confirmed by surgical pathology from October 2015 to 2016 were collected and the pelvic multistage DCE-MRI was performed before operation, and Extended Tofts and Exchange hemodynamics were selected. The quantitative perfusion parameters K~ (trans), PS, Fp, K_ (EP), V_e, V_p. were separately calculated and divided into 3 groups of cells, common type and degeneration type, and compared and analyzed the differences between the 3 groups of uterine myoma perfusion parameters. The statistical parameters were selected to draw the ROC curve of the differentiation of the myoma of the uterus; the Pearson phase was used. There was no correlation between the parameters between the two models. Results in the 3 groups of uterine myomas, the K~ (trans), Kep, Vp and Exchange models were Fp, K_ (EP), V_p values in the Extended Tofts model. The K~ (trans) in the Extended Toft model is related to the PS and Fp in the Exchange model (r=0.365, P=0.034, r=0.968, P=0.000), and there is a positive correlation between the two models. The value of Fp, K_ (EP) and V_p is of high value in the identification of cell myoma of the uterus, especially the K~ (trans) value in the Extended Tofts model and the Fp value in the Exchange model is the highest, and the two have obvious correlation. Meanwhile, the Extended Tofts model is better than the model.
【作者单位】： 浙江大学绍兴医院(绍兴市人民医院)放射科;绍兴市中心医院放射科;浙江大学医学院附属邵逸夫医院放射科;
【基金】：浙江省科技厅公益技术研究社会发展项目(编号:2014C33151) 浙江省医药卫生一般研究计划项目(编号:2014KYA215) 绍兴市公益性应用计划项目(编号:2013D10039)
【分类号】：R445.2;R737.33
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