基于静息态功能磁共振成像技术研究低频振幅下口服黄连苦味的中枢响应机制

发布时间：2018-07-18 16:32

【摘要】：目的:基于静息态功能磁共振脑成像(Rf MRI)技术,研究黄连苦味的中枢响应特点。方法:选择20各健康志愿者,收集口服黄连前后静息状态f MRI脑功能数据,并记录味觉评分表,采用SPM 8及REST 1.6软件分析数据得到低频振幅(ALFF)图,配对t检验分析,P0.001为差异有统计学意义。结果:口服黄连前后志愿者ALFF信号增加的脑区主要有双侧岛叶、右侧岛盖、右侧海马旁回、左侧额叶眶回等。ALFF信号信号降低主要有左侧岛盖、左侧海马旁回、左侧前上扣带回、右侧额叶眶回等。结论:黄连苦味对静息态脑网络活动有影响,以味觉中枢及情绪相关脑区表现明显。
[Abstract]:Aim: to study the central response of Coptis chinensis bitter taste based on resting functional magnetic resonance imaging (RF MRI). Methods: 20 healthy volunteers were selected to collect fMRI brain function data of resting state before and after oral administration of Coptis chinensis, and to record the taste score table. The low frequency amplitude (ALFF) map was obtained by SPM8 and REST1.6 software. There was significant difference in pairing t test analysis (P 0.001). Results: the increase of ALFF signal was mainly found in bilateral insular lobe, right insular cover, right perihippocampal gyrus, left frontal orbital gyrus and so on. The decrease of ALFF signal was mainly in left insular cap, left parahippocampal gyrus and left anterior superior cingulate gyrus. Right frontal lobe orbital gyrus etc. Conclusion: the bitter taste of Coptis chinensis has an effect on resting brain network activity, especially in the taste center and emotional related brain area.
【作者单位】： 成都中医药大学附属医院;成都中医药大学;
【基金】：四川省中医药管理局科研项目(No.2014-F030)~~
【分类号】：R285.6;R445.2
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